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0NUMB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNUMB
DescriptionProtein numb homolog (h-numb) (protein s171).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in the Numb family of proteins.
  IPR010449:NUMB phenylalanine-rich
The PI domain has a similar structure to the insulin receptor substrate-1 PTB domain. 7-stranded beta-sandwich.apped by a C-terminal helix.However.he PI domain contains an additional short N-terminal helix and alarge insertion between strands 1 and 2.hich forms a helix and 2 longconnecting loops. The substrate peptide fits into a surface cleft formedfrom the C-terminal helix and strand 5 .
  IPR006020:Phosphotyrosine interaction region
Pleckstrin homology (PH) domains are small modular domains that occur once.r occasionally several times.n a large variety of signalling proteins.here they serve as simple targeting domains that recognize only phosphoinositide headgroups . PH domains can target their host protein to the plasma and internal membranes through its association with phosphoinositides. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. Proteins containing PH domains include pleckstrin (N-terminal).hospholipase C delta-1.eta-spectrin.ynamin.on-of-sevenless.rp1.nc-89.app1 and Rac-alpha kinase.The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1).hc adaptor and Numb; to the Ran-binding domain.ound in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain).ound in Enabled.ASP (vasodilator-stimulated phosphoprotein).omer and WASP actin regulatory protein; to the third domain of FERM.ound in moesin.adixin.zrin.erlin and talin; and to the PH-like domain of neurobeachin.
  IPR011993:Pleckstrin homology-type
IPR010449:NumbF 
Evalue:-83.853874206543 
Location:173-329IPR006020:PID 
Evalue:-56.7958793640137 
Location:39-172
SequencesProtein: NUMB_HUMAN (651 aa)
mRNA: NM_001005743
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK06057
  Level 3 annotation:
    numb
  Level 2 annotation:
    Notch signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 695 residues, 72811670-72813754Exon2: 50 residues, 72815741-72815885Exon3: 51 residues, 72818819-72818966Exon4: 100 residues, 72820541-72820835Exon5: 70 residues, 72823570-72823775Exon6: 49 residues, 72829194-72829335Exon7: 27 residues, 72833671-72833746Exon8: 13 residues, 72852850-72852883Exon9: 27 residues, 72859590-72859665Exon10: 49 residues, 72892086-72892227Exon11: 30 residues, 72903357-72903442Exon12: 46 residues, 72946397-72946529Exon13: 31 residues, 72994951-72995039Exon14: 2 residues, -Jump to NUMB_HUMAN  
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Loci Cluster (Details)Loci: 2852 72672931-72756862 ~-84K 11422(PSEN1)(+)Loci: 4139 72811670-72995039 ~-183K 11431(NUMB)(-)Loci: 4138 72505912-72563592 ~-58K 11418(ZFYVE1)(-)Link out to UCSC