SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0NUDT9_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNUDT9
DescriptionAdp-ribose pyrophosphatase, mitochondrial precursor (ec 3.6.1.13) (adp-ribose diphosphatase) (adenosine diphosphoribose pyrophosphatase) (adpr-ppase) (adp-ribose phosphohydrolase) (nucleoside diphosphate- linked moiety x motif 9) (nudix motif 9).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (NAS)
0019144 ADP-sugar diphosphatase activity (NAS)
0005227 calcium activated cation channel activity (NAS)
0006812 cation transport (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/158777204.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
MutT is a small bacterial protein (~12-15Kd) involved in the GO system responsible for removing an oxidatively damaged form of guanine (8-hydroxy- guanine or 7.-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency.eading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.ith the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic.iral and eukaryotic proteins . The generic name NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family . The family can be divided into a number of subgroups.f which MutT anti- mutagenic activity represents only one type; most of the rest hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose.DP- mannose.DP-glucose.ADH.DP-sugars.NTP and NTP).
  IPR000086:NUDIX hydrolase
IPR000086:NUDIX 
Evalue:-5.0506100654602 
Location:179-301IPR000086:NUDIX 
Evalue:0 
Location:0-0
SequencesProtein: NUDT9_HUMAN (350 aa)
mRNA: NM_024047
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01515
  Level 3 annotation:
    ADP-ribose pyrophosphatase
  Level 2 annotation:
    Purine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 144 residues, 88562758-88563188Exon2: 82 residues, 88575156-88575396Exon3: 34 residues, 88578452-88578548Exon4: 31 residues, 88582004-88582091Exon5: 39 residues, 88589317-88589429Exon6: 51 residues, 88591764-88591911Exon7: 30 residues, 88594546-88594631Exon8: 169 residues, 88598018-88598521Exon9: 2 residues, -Jump to NUDT9_HUMAN  
Tune and view alternative isoforms