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0NUD17_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNUDT17
DescriptionPutative nucleoside diphosphate-linked moiety x motif 17, mitochondrial precursor (ec 3.6.1.-) (nudix motif 17).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
MutT is a small bacterial protein (~12-15Kd) involved in the GO system responsible for removing an oxidatively damaged form of guanine (8-hydroxy- guanine or 7.-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency.eading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.ith the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic.iral and eukaryotic proteins . The generic name NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family . The family can be divided into a number of subgroups.f which MutT anti- mutagenic activity represents only one type; most of the rest hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose.DP- mannose.DP-glucose.ADH.DP-sugars.NTP and NTP).
  IPR000086:NUDIX hydrolase
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
  IPR002110:Ankyrin
IPR000086:NUDIX 
Evalue:-14.4317979812622 
Location:91-237IPR002110:ANKYRIN 
Evalue:0 
Location:34-46IPR000086:NUDIX 
Evalue:0 
Location:0-0
SequencesProtein: NUD17_HUMAN (295 aa)
mRNA: NM_001012758
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01529
  Level 3 annotation:
    
  Level 2 annotation:
    Starch and sucrose metabolism
    Folate biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 66 residues, 144297851-144298048Exon2: 53 residues, 144298160-144298313Exon3: 47 residues, 144298705-144298842Exon4: 35 residues, 144299076-144299175Exon5: 33 residues, 144299734-144299827Exon6: 10 residues, 144299966-144299992Exon7: 63 residues, 144300228-144300412Exon8: 68 residues, 144300592-144300792Exon9: 2 residues, -Jump to NUD17_HUMAN  
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Loci Cluster (Details)Loci: 2545 144439082-144475430 ~-36K 2379(PDZK1)(+)Loci: 3827 144297851-144300792 ~-3K 2372(NUDT17)(-)Link out to UCSC