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0NUBM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNDUFV1
DescriptionNadh-ubiquinone oxidoreductase 51 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-51kd) (ci-51kd) (nadh dehydrogenase flavoprotein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005743 mitochondrial inner membrane (NAS)
0008137 NADH dehydrogenase (ubiquinone) activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Respiratory-chain NADH dehydrogenase () (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide subunits of this bioenergetic enzyme complex there is one with a molecular weight of 51 kDa (in mammals).hich is the second largest subunit of complex I and is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind to NAD.MN.nd a 2Fe-2S cluster. The 51 kDa subunit and the bacterial hydrogenase alpha subunit contain three regions of sequence similarities. The first one most probably corresponds to the NAD-binding site.he second to the FMN-binding site.nd the third one.hich contains three cysteines.o the iron-sulphur binding region.
  IPR011538:Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit
This entry describes the F chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone.biquinone.n mitochondria and most bacteria.ncluding Escherichia coli.here the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria.here the quinone may be plastoquinone and NADH may be replaced by NADPH.or in Methanosarcina.here NADH is replaced by F420H2.
  IPR011537:NADH-quinone oxidoreductase, F subunit
IPR011538:Complex1_51K 
Evalue:-182.744720458984 
Location:60-322IPR001949:COMPLEX1_51K_2 
Evalue:0 
Location:377-388
SequencesProtein: NUBM_HUMAN (464 aa)
mRNA: NM_007103
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK03942
  Level 3 annotation:
    NADH dehydrogenase (ubiquinone) flavoprotein 1
  Level 2 annotation:
    Oxidative phosphorylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 48 residues, 67130982-67131123Exon2: 29 residues, 67132442-67132525Exon3: 59 residues, 67132598-67132769Exon4: 63 residues, 67133498-67133682Exon5: 65 residues, 67134427-67134617Exon6: 73 residues, 67135041-67135254Exon7: 57 residues, 67135449-67135616Exon8: 29 residues, 67135943-67136025Exon9: 50 residues, 67136166-67136312Exon10: 56 residues, 67136418-67136581Exon11: 2 residues, -Jump to NUBM_HUMAN  
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Loci Cluster (Details)Loci: 2672 63498654-63500590 ~-2K 6992(COX8A)(+)Loci: 2673 63758841-63762834 ~-4K 7008(VEGFB)(+)Loci: 2674 63775570-63791969 ~-16K 7011(PLCB3)(+)Loci: 2675 63883200-63896262 ~-13K 7031(RPS6KA4)(+)Loci: 3958 64130223-64247236 ~-117K 7042(NRXN2)(-)Loci: 3959 64376783-64402767 ~-26K 7059(EHD1)(-)Loci: 2676 64551485-64564618 ~-13K 7071(SNX15)(+)Loci: 2677 64635935-64640274 ~-4K 7081(TM7SF2)(+)Loci: 2678 64705918-64736052 ~-30K 7088(CAPN1)(+)Loci: 2679 65049159-65062750 ~-14K 7102(+)Loci: 3960 65121802-65138296 ~-16K 7115(MAP3K11)(-)Loci: 3961 65407787-65412586 ~-5K 7136(FIBP)(-)Loci: 3962 65416267-65424573 ~-8K 7139(FOSL1)(-)Loci: 2680 65594399-65768789 ~-174K 7153(PACS1)(+)Loci: 2681 65792680-65801537 ~-9K 7155(RAB1B)(+)Loci: 2682 65815916-65820707 ~-5K 7159(+)Loci: 3963 65856117-65860576 ~-4K 7162(RIN1)(-)Loci: 2683 66140672-66151387 ~-11K 7189(RBM14)(+)Loci: 2684 66162753-66170514 ~-8K 7192(RBM4)(+)Loci: 3964 66209298-66245446 ~-36K 7194(SPTBN2)(-)Loci: 3965 66372572-66478456 ~-106K 7198(PC)(-)Loci: 2685 66547466-66574905 ~-27K 7200(SYT12)(+)Loci: 2686 66580896-66596059 ~-15K 7201(RHOD)(+)Loci: 3966 66922227-66925952 ~-4K 7219(PPP1CA)(-)Loci: 2687 66979393-66983261 ~-4K 7229(CABP4)(+)Loci: 2688 67130982-67136581 ~-6K 7239(NDUFV1)(+)Loci: 2689 67554684-67560690 ~-6K 7248(NDUFS8)(+)Loci: 2690 67836710-67973317 ~-137K 7259(LRP5)(+)Loci: 2671 63412650-63433621 ~-21K 6988(MARK2)(+)Link out to UCSC