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0NUAM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNDUFS1
DescriptionNadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-75kd) (ci-75kd).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0009055 electron carrier activity (TAS)
0008137 NADH dehydrogenase (ubiquinone) activity (TAS)
0006120 mitochondrial electron transport, NADH to u... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in a number of molybdopterin-containing oxidoreductases.ungsten formylmethanofuran dehydrogenase subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase subunit (FmdD); where a single domain constitutes almost the entire subunit. The formylmethanofuran dehydrogenase catalyses the first step in methane formation from CO2 in methanogenic archaea and has a molybdopterin dinucleotide cofactor .
  IPR006656:Molybdopterin oxidoreductase
The ferredoxin protein family are electron carrier proteins with an iron-sulphur cofactor that act in a wide variety of metabolic reactions. Ferredoxins can be divided into several subgroups depending upon the physiological nature of the iron-sulphur cluster(s) and according to sequence similarities. This entry represents members of the 2Fe-2S ferredoxin family that have a general core structure consisting of beta(2)-alpha-beta(2).hich includes putidaredoxin and terpredoxin.nd adrenodoxin . They are proteins of around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This conserved region is also found as a domain in various metabolic enzymes and in multidomain proteins.uch as aldehyde oxidoreductase (N-terminal).anthine oxidase (N-terminal).hthalate dioxygenase reductase (C-terminal).uccinate dehydrogenase iron-sulphur protein (N-terminal).nd methane monooxygenase reductase (N-terminal).
  IPR001041:Ferredoxin
This entry represents the G subunit (one of 14 subunits. to N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria while translocating protons.ut may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This family does not contain related subunits from formate dehydrogenase complexes.
  IPR010228:NADH-quinone oxidoreductase, chain G
The ferredoxin protein family are electron carrier proteins with an iron-sulphur cofactor that act in a wide variety of metabolic reactions. Ferredoxins can be divided into several subgroups depending upon the physiological nature of the iron-sulphur cluster(s) and according to sequence similarities. This entry represents members of the 2Fe-2S ferredoxin family that have a general core structure consisting of beta(2)-alpha-beta(2).hich includes putidaredoxin and terpredoxin.nd adrenodoxin . This entry also represents 2Fe-2S ferredoxin domains from multidomain proteins.uch as aldehyde oxidoreductase (N-terminal).anthine oxidase (N-terminal).hthalate dioxygenase reductase (C-terminal).uccinate dehydrogenase iron-sulphur protein (N-terminal).nd methane monooxygenase reductase (N-terminal). In addition.his entry includes the N-terminal additional domain of threonyl-tRNA synthetase (ThrRS). class II multi-domain enzyme that represses its own translation; the N-terminal additional domain has a beta(2)-alpha-beta(2) core structure .
  IPR012675:2Fe-2S Ferredoxin-like fold
IPR006656:Molybdopterin 
Evalue:-151.481491088867 
Location:301-629IPR001041:Fer2 
Evalue:-12.6777811050415 
Location:34-98IPR000283:COMPLEX1_75K_2 
Evalue:0 
Location:128-140IPR000283:COMPLEX1_75K_3 
Evalue:0 
Location:175-185IPR006058:2FE2S_FER_1 
Evalue:0 
Location:0-0
SequencesProtein: NUAM_HUMAN (727 aa)
mRNA: NM_005006
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK03934
  Level 3 annotation:
    NADH dehydrogenase (ubiquinone) Fe-S protein 1
  Level 2 annotation:
    Oxidative phosphorylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 400 residues, 206696048-206697245Exon2: 26 residues, 206699507-206699580Exon3: 47 residues, 206699678-206699813Exon4: 60 residues, 206700765-206700941Exon5: 53 residues, 206703056-206703211Exon6: 55 residues, 206705913-206706074Exon7: 45 residues, 206711453-206711583Exon8: 45 residues, 206714909-206715038Exon9: 50 residues, 206715654-206715800Exon10: 40 residues, 206716986-206717101Exon11: 47 residues, 206717860-206717995Exon12: 64 residues, 206719871-206720057Exon13: 45 residues, 206720499-206720630Exon14: 29 residues, 206720721-206720803Exon15: 27 residues, 206721988-206722065Exon16: 38 residues, 206722786-206722894Exon17: 32 residues, 206725387-206725479Exon18: 23 residues, 206726586-206726651Exon19: 43 residues, 206732309-206732432Exon20: 2 residues, -Jump to NUAM_HUMAN  
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