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0NTR2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNTSR2
DescriptionNeurotensin receptor type 2 (nt-r-2) (levocabastine-sensitive neurotensin receptor) (ntr2 receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0007600 sensory perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neurotensin is a 13-residue peptide transmitter.haring significantsimilarity in its 6 C-terminal amino acids with several other neuropeptides.ncluding neuromedin N. This region is responsible for the biological activity.he N-terminal portion having a modulatory role. Neurotensin is distributed throughout the central nervous system.ith highest levels in the hypothalamus.mygdala and nucleus accumbens. It induces a variety of effects.ncluding: analgesia.ypothermia and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery.eurotensin is found in endocrine cells of the small intestine.here it leads to secretion and smooth muscle contraction .The existence of 2 neurotensin receptor subtypes.ith differing affinitiesfor neurotensin and differing sensitivities to the antihistamine levocabastine.as originally demonstrated by binding studies in rodent brain. Two neurotensin receptors (NT1 and NT2) with such properties have since been cloned and have been found to be G-protein-coupled receptor family members .
  IPR003984:Neurotensin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neurotensin is a 13-residue peptide transmitter.haring significantsimilarity in its 6 C-terminal amino acids with several other neuropeptides.ncluding neuromedin N. This region is responsible for the biological activity.he N-terminal portion having a modulatory role. Neurotensin is distributed throughout the central nervous system.ith highest levels in the hypothalamus.mygdala and nucleus accumbens. It induces a variety of effects.ncluding: analgesia.ypothermia and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery.eurotensin is found in endocrine cells of the small intestine.here it leads to secretion and smooth muscle contraction .The existence of 2 neurotensin receptor subtypes.ith differing affinitiesfor neurotensin and differing sensitivities to the antihistamine levocabastine.as originally demonstrated by binding studies in rodent brain. Two neurotensin receptors (NT1 and NT2) with such properties have since been cloned and have been found to be G-protein-coupled receptor family members .The NT2 receptor was cloned from rat.ouse and human brains based on itssimilarity to the NT1 receptor. The receptor was found to be a low affinity.evocabastine sensitive receptor for neurotensin. Unlike the high affinity.T1 receptor.T2 is insensitive to guanosine triphosphate and has low sensitivity to sodium ions . Highest levels of expression of the receptor are found in the brain.n regions including: the olfactory system.erebral and cerebellar cortices.ippocampus and hypothalamic nuclei. The distribution is distinct from that of the NT1 receptor.ith only a fewareas (diagonal band of Broca.edial septal nucleus and suprachiasmatic nuclei) expressing both receptor subtypes. The receptor has also been found at lower levels in the kidney.terus.eart and lung . Activationof the NT2 receptor by non-peptide agonists suggests that the receptor cancouple to phospholipase C.hospholipase A2 and MAP kinase. A functionalresponse to neurotensin.owever.s weak or absent.nd neurotensin appears to act as an antagonist of the receptor . It has been suggested that a substance other than neurotensin may act as the natural ligand for this receptor.
  IPR003986:Neurotensin type 2 receptor
IPR000276:7tm_1 
Evalue:-42.9208183288574 
Location:49-358IPR003986:NEUROTENSN2R 
Evalue:0 
Location:14-26IPR003986:NEUROTENSN2R 
Evalue:0 
Location:1-13IPR003984:NEUROTENSINR 
Evalue:0 
Location:368-378IPR003984:NEUROTENSINR 
Evalue:0 
Location:29-39
SequencesProtein: NTR2_HUMAN (410 aa)
mRNA: NM_012344
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04212
  Level 3 annotation:
    neurotensin receptor 2
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 182 residues, 11715755-11716299Exon2: 32 residues, 11717619-11717710Exon3: 93 residues, 11719543-11719817Exon4: 266 residues, 11727082-11727876Exon5: 2 residues, -Jump to NTR2_HUMAN  
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