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0NTR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNTSR1
DescriptionNeurotensin receptor type 1 (nt-r-1) (high-affinity levocabastine- insensitive neurotensin receptor) (ntrh).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0005794 Golgi apparatus (TAS)
0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neurotensin is a 13-residue peptide transmitter.haring significantsimilarity in its 6 C-terminal amino acids with several other neuropeptides.ncluding neuromedin N. This region is responsible for the biological activity.he N-terminal portion having a modulatory role. Neurotensin is distributed throughout the central nervous system.ith highest levels in the hypothalamus.mygdala and nucleus accumbens. It induces a variety of effects.ncluding: analgesia.ypothermia and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery.eurotensin is found in endocrine cells of the small intestine.here it leads to secretion and smooth muscle contraction .The existence of 2 neurotensin receptor subtypes.ith differing affinitiesfor neurotensin and differing sensitivities to the antihistamine levocabastine.as originally demonstrated by binding studies in rodent brain. Two neurotensin receptors (NT1 and NT2) with such properties have since been cloned and have been found to be G-protein-coupled receptor family members .
  IPR003984:Neurotensin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neurotensin is a 13-residue peptide transmitter.haring significantsimilarity in its 6 C-terminal amino acids with several other neuropeptides.ncluding neuromedin N. This region is responsible for the biological activity.he N-terminal portion having a modulatory role. Neurotensin is distributed throughout the central nervous system.ith highest levels in the hypothalamus.mygdala and nucleus accumbens. It induces a variety of effects.ncluding: analgesia.ypothermia and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery.eurotensin is found in endocrine cells of the small intestine.here it leads to secretion and smooth muscle contraction .The existence of 2 neurotensin receptor subtypes.ith differing affinitiesfor neurotensin and differing sensitivities to the antihistamine levocabastine.as originally demonstrated by binding studies in rodent brain. Two neurotensin receptors (NT1 and NT2) with such properties have since been cloned and have been found to be G-protein-coupled receptor family members .The NT1 receptor was cloned in 1990 from rat brain and found to act as ahigh affinity.evocabastine insensitive receptor for neurotensin . The affinity of neurotensin for the receptor could be decreased by both sodium ions and guanosine triphosphate (GTP) . The NT1 receptor is expressed predominantly in the brain and intestine. In the brain.xpression has been found in the diagonal band of Broca.edial septal nucleus.ucleus basalis magnocellularis.uprachiasmatic nucleus.upramammillary area.ubstantia nigra and ventral tegmental area. The receptor is also expressed in the dorsal root ganglion neurones of the spinal cord. The predominant response upon activation of the receptor by neurotensin is activation of phospholipase C.ausing an increase in intracellular calcium levels. The receptor can also stimulate cAMP formation.AP kinase activation and the induction of growth related genes.uch as krox-24 .
  IPR003985:Neurotensin type 1 receptor
IPR000276:7tm_1 
Evalue:-78.3565444946289 
Location:80-364IPR003985:NEUROTENSN1R 
Evalue:0 
Location:393-411IPR003984:NEUROTENSINR 
Evalue:0 
Location:374-384IPR003984:NEUROTENSINR 
Evalue:0 
Location:60-70IPR003985:NEUROTENSN1R 
Evalue:0 
Location:37-46
SequencesProtein: NTR1_HUMAN (418 aa)
mRNA: NM_002531
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04211
  Level 3 annotation:
    neurotensin receptor 1
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 362 residues, 60810633-60811718Exon2: 69 residues, 60856481-60856683Exon3: 32 residues, 60860062-60860153Exon4: 919 residues, 60861814-60864567Exon5: 2 residues, -Jump to NTR1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC