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0NRTN_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNRTN
DescriptionNeurturin precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005102 receptor binding (TAS)
0000165 MAPKKK cascade (TAS)
0007399 neurogenesis (TAS)
0007169 transmembrane receptor protein tyrosine kin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation.ifferentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.A number of proteins are known to be related to TGF-beta-1 . Proteins from the TGF-beta family are only active as homo- or heterodimer; the two chains being linked by a single disulphide bond. From X-ray studies of TGF-beta-2 .t is known that all the other cysteines are involved in intrachain disulphide bonds. As shown in the following schematic representation.here are four disulphide bonds in the TGF-betas and in inhibin beta chains.hile the other members of this family lack the first bond.
  IPR001839:Transforming growth factor beta
The crystal structures of several proteins have been reported as having unusual folds.nvolving intramolecular disulphide bridges. In transforming growth factor-beta 2 (TGF-beta2) .latelet-derived growth factor (PDGF).erve growth factor (NGF) and human chorionic gonadotropin (hCG) .ix conserved cysteines (I to VI in sequence order) form three disulphide links arranged in a knot-like topology. Cystines [II-V] and [III-VI] form a ring of eight amino acids through which the remaining disulphide bond (Cys[I-IV]) penetrates.A similar knotted arrangement of disulphide bonds has been noted in the structures of some enzyme inhibitors and neurotoxins that bind to voltage- gated Ca2+ channels . In those sequences.owever.he cystine topology differs. Cys[III-VI] penetrates a macrocyclic ring formed by Cys[I-IV] and Cys[II-V]. Thus.ystine knots fall into two structural classes: growth factor type and inhibitor-like cystine knots .All growth factor cystine knots structures have similar topology.ith two distorted beta-hairpin loops "above" the knot and a single loop "below". The sizes of the hairpin loop vary significantly.
  IPR002400:Growth factor, cystine knot
IPR001839:TGF_beta 
Evalue:-41.8860549926758 
Location:100-197IPR001839:TGF_BETA_1 
Evalue:0 
Location:0-0
SequencesProtein: NRTN_HUMAN (197 aa)
mRNA: NM_004558
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 177 residues, 5774817-5775345Exon2: 193 residues, 5778759-5779334Exon3: 2 residues, -Jump to NRTN_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3082 5774817-5779334 ~-5K 17769(NRTN)(+)Loci: 4357 5642845-5671176 ~-28K 17762(PRSS15)(-)Link out to UCSC