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0NPY2R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNPY2R
DescriptionNeuropeptide y receptor type 2 (npy2-r) (npy-y2 receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005246 calcium channel regulator activity (TAS)
0004983 neuropeptide Y receptor activity (TAS)
0004872 receptor activity (TAS)
0007193 G-protein signaling, adenylate cyclase inhi... (TAS)
0007626 locomotory behavior (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide Y (NPY) is one of the most abundant peptides in mammalianbrain.nducing a variety of behavioural effects (e.g..timulation of foodintake.nxiety.acilitation of learning and memory.nd regulation of thecardiovascular and neuroendocrine systems). In the periphery.PYstimulates vascular smooth muscle contraction and modulates hormonesecretion. NPY has been implicated in the pathophysiology of hypertension.ongestive heart failure.ffective disorders and appetite regulation .
  IPR000611:Neuropeptide Y receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide Y (NPY) is one of the most abundant peptides in mammalianbrain.nducing a variety of behavioural effects (e.g..timulation of foodintake.nxiety.acilitation of learning and memory.nd regulation of thecardiovascular and neuroendocrine systems). In the periphery.PYstimulates vascular smooth muscle contraction and modulates hormonesecretion. NPY has been implicated in the pathophysiology of hypertension.ongestive heart failure.ffective disorders and appetite regulation .Several pharmacologically distinct neuropeptide Y receptors have beencharacterised.esignated NPY Y1-Y6. High densities of Y2 receptors arepresent in rat hippocampus and are also found in high levels in superficiallayers of cortex.ertain thalamic nuclei.ateral septum.nd anteriorolfactory nuclei; lower levels are found in striatum. The receptors arefound in high levels in smooth muscle (e.g..as deferens and intestine).idney proximal tubules and in cell lines. They are believed to have apredominantly presynaptic location.nd are involved in inhibition ofadenylyl cyclase and voltage dependent calcium channels via a pertussis-toxin-sensitive G-protein.robably of the G0/Gi class .
  IPR001358:Neuropeptide Y2 receptor
IPR000276:7tm_1 
Evalue:-64.6989669799805 
Location:67-325IPR001358:NRPEPTIDEY2R 
Evalue:0 
Location:42-59IPR001358:NRPEPTIDEY2R 
Evalue:0 
Location:2-19IPR001358:NRPEPTIDEY2R 
Evalue:0 
Location:335-351IPR001358:NRPEPTIDEY2R 
Evalue:0 
Location:365-380
SequencesProtein: NPY2R_HUMAN (381 aa)
mRNA: NM_000910
Local Annotation
Synapse Ontology
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:domains)
long-term depression is the opposite to LTP. LTD means a decrease in the synaptic strength that could last for more than 5 mins. It is typically evoked by brief, strong stimulation.
sdb:0213 LTD  (Evidence:domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
components of the signal transduction machinery for LTP are all the molecules that are involved in the LTP transduction machinery.
sdb:0251 components of the signal transduction machinery for LTP  (Evidence:domains)
KO assignmentK04205
  Level 3 annotation:
    neuropeptide Y receptor Y2
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 148 residues, 156349230-156349671Exon2: 1063 residues, 156354493-156357676Exon3: 2 residues, -Jump to NPY2R_HUMAN  
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