SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0NPFF2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGPR74
DescriptionNeuropeptide ff receptor 2 (neuropeptide g-protein coupled receptor) (g-protein coupled receptor 74) (g-protein coupled receptor hlwar77).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0009582 detection of abiotic stimulus (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1811442861.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide FF (and neuropeptide AF.hich is also derived from the same precursor) belong to a family of neuropeptides containing an RF-amide motif at their C-terminus. Neuropeptide FF (NPFF) is found at high concentrations in the posterior pituitary.pinal cord.ypothalamus and medulla and is believed to be involved in pain modulation.pioid tolerance.ardiovascular regulation.emory and neuroendocrine regulation . Two G protein-coupled receptors for NPFF have been identified; both are expressed in the central nervous system and couple to Gi proteins to inhibit adenylyl cyclase .
  IPR005395:Neuropeptide FF receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide FF (and neuropeptide AF.hich is also derived from the same precursor) belong to a family of neuropeptides containing an RF-amide motif at their C-terminus. Neuropeptide FF (NPFF) is found at high concentrations in the posterior pituitary.pinal cord.ypothalamus and medulla and is believed to be involved in pain modulation.pioid tolerance.ardiovascular regulation.emory and neuroendocrine regulation . Two G protein-coupled receptors for NPFF have been identified; both are expressed in the central nervous system and couple to Gi proteins to inhibit adenylyl cyclase . The type 2 neuropeptide FF receptor is expressed at high levels in the thymus and placenta.ith moderate levels in the pituitary.pleen.estis and brain. Low levels were detected in the spinal cord.ancreas.mall intestine.terus.tomach.ung.eart and skeletal muscle. No expression was detected in liver or kidney .
  IPR005397:Neuropeptide FF receptor, type 2
IPR000276:7tm_1 
Evalue:-73.3187561035156 
Location:164-435IPR005397:NPFFRECEPTR2 
Evalue:0 
Location:106-124IPR005397:NPFFRECEPTR2 
Evalue:0 
Location:455-470IPR005395:NPFFRECEPTOR 
Evalue:0 
Location:133-146IPR005397:NPFFRECEPTR2 
Evalue:0 
Location:510-521IPR005395:NPFFRECEPTOR 
Evalue:0 
Location:440-450
SequencesProtein: NPFF2_HUMAN (522 aa)
mRNA: NM_004885
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentK04240
  Level 3 annotation:
    RFamide-related peptide receptor
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 133 residues, 73116384-73116781Exon2: 113 residues, 73213165-73213500Exon3: 35 residues, 73222620-73222720Exon4: 363 residues, 73231558-73232643Exon5: 2 residues, -Jump to NPFF2_HUMAN  
Tune and view alternative isoforms