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0NPB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNPB
DescriptionNeuropeptide b precursor (preproprotein l7) (hppl7) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Two closely related neuropeptide precursors.hich share no significant sequence similarity with other known neuropeptides.ave recently been identified and named preproneuropeptide B and preproneuropeptide W . In humans.ach precursor contains a signal sequence and two dibasic cleavage sites. Alternative cleavage of these sites results in long (29 or 30 amino acid) and short (23 amino acid) forms of the resultant neuropeptides . Murine.at and bovine versions of preproneuropeptide B.owever.ontain only the second cleavage site.esulting in only the long form of neuropeptide B . Neuropeptide B is expressed in both the central nervous system (CNS) and in the periphery. In the CNS.he highest levels of the peptide are found in the substantia nigra and hypothalamus.uggesting a possible role in locomotor control and the release of pituitary hormones . In the periphery.he peptide is most abundant in testis.vary.terus.lacenta.pleen.ymph nodes and peripheral blood leukocytes.ndicating potential roles in the reproductive and immune systems . Unusually.europeptide B purified from bovine hypothalamus was found to be brominated at its N-terminus . Neuropeptide W has a more limited distribution in the brain than neuropeptide B.nd is found at highest levels in the substantia nigra.gain suggesting an involvement in locomotor control . In the periphery.europeptide W is more widespread than neuropeptide B. In addition to the reproductive and immune tissues in which neuropeptide B is expressed.europeptide W has been found at high levels in the liver.tomach and trachea . Intracerebroventricular administration of neuropeptide W in rats has been reported to produce an acute increase in food intake and to stimulate prolactin release .
  IPR013297:Neuropeptide B/W precursor
Two closely related neuropeptide precursors.hich share no significant sequence similarity with other known neuropeptides.ave recently been identified and named preproneuropeptide B and preproneuropeptide W . In humans.ach precursor contains a signal sequence and two dibasic cleavage sites. Alternative cleavage of these sites results in long (29 or 30 amino acid) and short (23 amino acid) forms of the resultant neuropeptides . Murine.at and bovine versions of preproneuropeptide B.owever.ontain only the second cleavage site.esulting in only the long form of neuropeptide B . Neuropeptide B is expressed in both the central nervous system (CNS) and in the periphery. In the CNS.ighest levels of the peptide are found in the substantia nigra and hypothalamus.uggesting a possible role in locomotor control and the release of pituitary hormones . In the periphery.he peptide is most abundant in testis.vary.terus.lacenta.pleen.ymph nodes and peripheral blood leukocytes.ndicating potential roles in the reproductive and immune systems . Unusually.europeptide B purified from bovine hypothalamus was found to be brominated at its N-terminus .
  IPR013298:Neuropeptide B precursor
IPR013298:PPNRPEPTIDEB 
Evalue:0 
Location:104-117IPR013298:PPNRPEPTIDEB 
Evalue:0 
Location:89-100IPR013297:NROPEPTIDEBW 
Evalue:0 
Location:24-34IPR013297:NROPEPTIDEBW 
Evalue:0 
Location:45-55IPR013298:PPNRPEPTIDEB 
Evalue:0 
Location:77-87
SequencesProtein: NPB_HUMAN (125 aa)
mRNA: AF525737 BC033173
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 719 residues, 77451912-77454066Exon2: 2 residues, -Jump to NPB_HUMANExon1: 93 residues, 77453416-77453694Exon2: 53 residues, 77453787-77453940Exon3: 2 residues, -Jump to NPB_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 93 residues, 2419706-2419984Exon2: 53 residues, 2420078-2420231Exon3: 2 residues, -Jump to NPB_HUMAN  
Loci Cluster (Details)Loci: 4323 76816673-76827450 ~-11K 16811(-)Loci: 4324 77091593-77094422 ~-3K 16823(ACTG1)(-)Loci: 3047 77261424-77279550 ~-18K 16838(HGS)(+)Loci: 3048 77451912-77454066 ~-2K 16852(NPB)(+)Loci: 3049 77603051-77608635 ~-6K 16881(GPS1)(+)Loci: 4325 77629503-77649395 ~-20K 16888(FASN)(-)Loci: 4326 77795530-77824862 ~-29K 16893(CSNK1D)(-)Loci: 4327 78208237-78249802 ~-42K 16919(RAB40B)(-)Loci: 3046 76623556-76705827 ~-82K 16801(BAIAP2)(+)Link out to UCSC