SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0NOVA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNOVA2
DescriptionRna-binding protein nova-2 (neuro-oncological ventral antigen 2) (astrocytic nova1-like rna-binding protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003723 RNA binding (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The K homology (KH) domain was first identified in the human heterogeneousnuclear ribonucleoprotein (hnRNP) K. It is a domain of around 70 amino acidsthat is present in a wide variety of quite diverse nucleic acid-bindingproteins . It has been shown to bind RNA . Like many other RNA-binding motifs.H motifs are found in one or multiple copies (14 copies in chicken vigilin) and.t least for hnRNP K (three copies) and FMR-1 (two copies).ach motif is necessary for in vitro RNA binding activity.uggesting that they may function cooperatively or.n the case of single KH motif proteins (for example.er1p).ndependently .According to structural analysis the KH domain can be separated in two groups. The first group or type-1 contain a beta-alpha-alpha-beta-beta-alpha structure.hereas in the type-2 the two last beta-sheet are located in the N terminal part of the domain (alpha-beta-beta-alpha-alpha-beta). Sequence similarity between these two folds are limited to a short region (VIGXXGXXI) in the RNA binding motif. This motif is located between helice 1 and 2 in type-1 and between helice 2 and 3 in type-2. Proteins known to contain a type-1 KH domain include bacterial polyribonucleotide nucleotidyltransferases (); vertebrate fragile X mental retardation protein 1 (FMR1); eukaryotic heterogeneous nuclear ribonucleoprotein K (hnRNP K).ne of at least 20 major proteins that are part of hnRNP particles in mammalian cells; mammalian poly(rC) binding proteins; Artemia salina glycine-rich protein GRP33; yeast PAB1-binding protein 2 (PBP2); vertebrate vigilin; and human high-density lipoprotein binding protein (HDL-binding protein).
  IPR004088:KH, type 1
The K homology (KH) domain was first identified in the human heterogeneousnuclear ribonucleoprotein (hnRNP) K. It is an evolutionarily conservedsequence of around 70 amino acids that is present in a wide variety of quitediverse nucleic acid-binding proteins. Although it is not strictly proven theKH domain is suspected to bind RNA. Like many other RNA-binding motifs.Hmotifs are found in one or multiple copies (14 copies in chicken vigilin) and.t least for hnRNP K (three KH domains) and FMR-1 (two KH domains).ach motifis necessary for in vitro RNA binding activity.uggesting that they mayfunction cooperatively or.n the case of single KH motif proteins (forexample.er1p).ndependently . The domain has been found in a number of proteins including eukaryotic and prokaryotic RS3 ribosomal proteins; vertebrate fragile X mental retardation protein 1 (FMR1); yeast Pab1-binding protein 2 PBP2; human high-density lipoprotein binding protein; and human onconeural ventral antigen-1 (NOVA-1).The solution structure of the first KH domain of FMR1 and of theC-terminal KH domain of hnRNP K determined by nuclear magnetic resonance(NMR) revealed a beta-alpha-alpha-beta-beta-alpha structure.
  IPR004087:KH
IPR004088:KH_1 
Evalue:-18.3372421264648 
Location:408-473IPR004088:KH_1 
Evalue:-18.0705814361572 
Location:132-196IPR004088:KH_1 
Evalue:-15.6777811050415 
Location:34-99
SequencesProtein: NOVA2_HUMAN (492 aa)
mRNA: NM_002516
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 472 residues, 51134630-51136043Exon2: 57 residues, 51148877-51149044Exon3: 50 residues, 51156107-51156251Exon4: 46 residues, 51168364-51168497Exon5: 2 residues, -Jump to NOVA2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3116 50100878-50104489 ~-4K 19057(APOE)(+)Loci: 3117 50234137-50266053 ~-32K 19065(SFRS16)(+)Loci: 4398 50407718-50429309 ~-22K 19076(-)Loci: 3118 50446389-50500381 ~-54K 19078(MARK4)(+)Loci: 4399 50546685-50565669 ~-19K 19089(ERCC2)(-)Loci: 4400 50747641-50779917 ~-32K 19109(OPA3)(-)Loci: 4401 50804499-50834509 ~-30K 19111(EML2)(-)Loci: 3119 50863341-50877557 ~-14K 19113(GIPR)(+)Loci: 4402 51134630-51168497 ~-34K 19134(NOVA2)(-)Loci: 3120 51542133-51585943 ~-44K 19149(PPP5C)(+)Loci: 3121 51796351-51805878 ~-10K 19157(CALM1)(+)Loci: 4403 51869413-51911506 ~-42K 19161(PRKD2)(-)Loci: 4404 52033262-52046043 ~-13K 19167(AP2S1)(-)Loci: 3115 50004177-50016517 ~-12K 19053(LU)(+)Link out to UCSC