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0NOVA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNOVA1
DescriptionRna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen 1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003723 RNA binding (TAS)
0007626 locomotory behavior (TAS)
0008380 RNA splicing (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The K homology (KH) domain was first identified in the human heterogeneousnuclear ribonucleoprotein (hnRNP) K. It is a domain of around 70 amino acidsthat is present in a wide variety of quite diverse nucleic acid-bindingproteins . It has been shown to bind RNA . Like many other RNA-binding motifs.H motifs are found in one or multiple copies (14 copies in chicken vigilin) and.t least for hnRNP K (three copies) and FMR-1 (two copies).ach motif is necessary for in vitro RNA binding activity.uggesting that they may function cooperatively or.n the case of single KH motif proteins (for example.er1p).ndependently .According to structural analysis the KH domain can be separated in two groups. The first group or type-1 contain a beta-alpha-alpha-beta-beta-alpha structure.hereas in the type-2 the two last beta-sheet are located in the N terminal part of the domain (alpha-beta-beta-alpha-alpha-beta). Sequence similarity between these two folds are limited to a short region (VIGXXGXXI) in the RNA binding motif. This motif is located between helice 1 and 2 in type-1 and between helice 2 and 3 in type-2. Proteins known to contain a type-1 KH domain include bacterial polyribonucleotide nucleotidyltransferases (); vertebrate fragile X mental retardation protein 1 (FMR1); eukaryotic heterogeneous nuclear ribonucleoprotein K (hnRNP K).ne of at least 20 major proteins that are part of hnRNP particles in mammalian cells; mammalian poly(rC) binding proteins; Artemia salina glycine-rich protein GRP33; yeast PAB1-binding protein 2 (PBP2); vertebrate vigilin; and human high-density lipoprotein binding protein (HDL-binding protein).
  IPR004088:KH, type 1
The K homology (KH) domain was first identified in the human heterogeneousnuclear ribonucleoprotein (hnRNP) K. It is an evolutionarily conservedsequence of around 70 amino acids that is present in a wide variety of quitediverse nucleic acid-binding proteins. Although it is not strictly proven theKH domain is suspected to bind RNA. Like many other RNA-binding motifs.Hmotifs are found in one or multiple copies (14 copies in chicken vigilin) and.t least for hnRNP K (three KH domains) and FMR-1 (two KH domains).ach motifis necessary for in vitro RNA binding activity.uggesting that they mayfunction cooperatively or.n the case of single KH motif proteins (forexample.er1p).ndependently . The domain has been found in a number of proteins including eukaryotic and prokaryotic RS3 ribosomal proteins; vertebrate fragile X mental retardation protein 1 (FMR1); yeast Pab1-binding protein 2 PBP2; human high-density lipoprotein binding protein; and human onconeural ventral antigen-1 (NOVA-1).The solution structure of the first KH domain of FMR1 and of theC-terminal KH domain of hnRNP K determined by nuclear magnetic resonance(NMR) revealed a beta-alpha-alpha-beta-beta-alpha structure.
  IPR004087:KH
IPR004088:KH_1 
Evalue:-18.7958793640137 
Location:426-491IPR004088:KH_1 
Evalue:-18.3872165679932 
Location:176-240IPR004088:KH_1 
Evalue:-14.8860569000244 
Location:51-119
SequencesProtein: NOVA1_HUMAN (510 aa)
mRNA: NM_002515
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1027 residues, 25984929-25988009Exon2: 26 residues, 26011365-26011437Exon3: 57 residues, 26019022-26019189Exon4: 50 residues, 26134455-26134599Exon5: 153 residues, 26136346-26136800Exon6: 2 residues, -Jump to NOVA1_HUMAN  
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