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0NOP5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNOP5
DescriptionNucleolar protein nop5 (nucleolar protein 5) (nop58).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005730 nucleolus (TAS)
0030519 snoRNP binding (ISS)
0051082 unfolded protein binding (ISS)
0016049 cell growth (TAS)
0006364 rRNA processing (TAS)
0006608 snRNP protein-nucleus import (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This N-terminal domain is found in RNA-binding proteins of the NOP5 family .
  IPR012974:NOP5, N-terminal
This is the central domain in Nop56/SIK1-like proteins .
  IPR012976:NOSIC
This domain is present in various pre-mRNA processing ribonucleoproteins. The function of the domain is unknown however it may be a common RNA or snoRNA or Nop1p binding domain.Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases.TPases.r protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have also been described. Finally.rowing evidence suggests that proteins may contribute directly to the spliceosomes active sites .
  IPR002687:Pre-mRNA processing ribonucleoprotein, binding region
IPR002687:Nop 
Evalue:-95.1739273071289 
Location:253-401IPR012974:NOP5NT 
Evalue:-32.3279037475586 
Location:1-66IPR012976:NOSIC 
Evalue:-31.7447280883789 
Location:161-213
SequencesProtein: NOP5_HUMAN (529 aa)
mRNA: NM_015934
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 66 residues, 202838759-202838954Exon2: 27 residues, 202848080-202848157Exon3: 19 residues, 202850917-202850970Exon4: 42 residues, 202855318-202855440Exon5: 47 residues, 202857312-202857449Exon6: 23 residues, 202860627-202860692Exon7: 47 residues, 202863290-202863425Exon8: 50 residues, 202864092-202864238Exon9: 44 residues, 202865744-202865871Exon10: 56 residues, 202868641-202868805Exon11: 47 residues, 202870346-202870481Exon12: 22 residues, 202870812-202870874Exon13: 46 residues, 202873201-202873335Exon14: 47 residues, 202875888-202876025Exon15: 93 residues, 202876353-202876627Exon16: 2 residues, -Jump to NOP5_HUMAN  
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