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0NOE2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionNoelin-2 precursor (olfactomedin-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: LPH1.PH2 and LPH3. LPH1 is a brain-specific calciumindependent receptor of alpha-latrotoxin (LTX). neurotoxin. It is theaffinity of this form of the receptor for LTX that gives the family its name. LPH2 and LPH3.hilst sharing extensive sequence similarity to LPH1.o not bind LTX. LPH2 is distributed throughout most tissues.hereas LPH3 is also brain-specific . The endogenous ligand(s) for these receptors are at present unknown. Binding of LTX to LPH1 stimulates exocytosis and thesubsequent release of large amounts of neurotransmitters from neuronal andendocrine cells. The latrophilins possess up to 7 sites of alternative splicing; the resulting number of possible splice variants leads to a highly variable family of proteins.
  IPR003924:Latrophilin receptor
InterPro domains unassigned to SynO:
The olfactomedin-domain was first identified in olfactomedin.n extracellular matrix protein of the olfactory neuroepithelium . Members of this extracellular domain-family have since been shown to be present in several metazoan proteins.uch as latrophilins.yocilins.ptimedins and noelins.he latter being involved in the generation of neural crest cells. Myocilin is of considerable interest.s mutations in its olfactomedin-domain can lead to glaucoma . The olfactomedin-domains in myocilin and optimedin are essential for the interaction between these two proteins .
SequencesProtein: NOE2_HUMAN (454 aa)
mRNA: NM_058164
Local Annotation
Synapse Ontology
some genes' expression is great dependent on the calcium, so calcium can regulate their expression.
sdb:0199 calcium regulation of transcription  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 382 residues, 9825394-9826539Exon2: 37 residues, 9828482-9828589Exon3: 75 residues, 9828938-9829158Exon4: 51 residues, 9829390-9829537Exon5: 52 residues, 9832320-9832470Exon6: 32 residues, 9907979-9908070Exon7: 2 residues, -Jump to NOE2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4364 10305453-10311300 ~-6K 17970(ICAM3)(-)Loci: 4365 10544347-10558991 ~-15K 17988(AP1M2)(-)Loci: 3088 10689754-10803579 ~-114K 18002(DNM2)(+)Loci: 3089 10843252-10894447 ~-51K 18009(CARM1)(+)Loci: 3090 11061131-11105490 ~-44K 18013(LDLR)(+)Loci: 4366 11296093-11311321 ~-15K 18027(RAB3D)(-)Loci: 4363 9825394-9908070 ~-83K 17941(OLFM2)(-)Link out to UCSC