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0NMDE4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGRIN2D
DescriptionGlutamate receptor subunit epsilon 4 precursor (n-methyl d- aspartate receptor subtype 2d) (nr2d) (nmdar2d) (eb11).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0007165 signal transduction (NAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are three classes of ionotropic glutamate receptor.amely NMDA (N-methyl-D-aspartate).MPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionicacid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain.ransient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission .
  IPR001320:Ionotropic glutamate receptor
InterPro domains unassigned to SynO:
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
N-Methyl-D-aspartate (NMDA) receptors are members of the glutamate receptorchannel superfamily.hich mediate most of the fast excitory synaptictransmissions in the central nervous system. The superfamily consists of 3subtypes: kainate receptors.lpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors and N-methyl-D-aspartate (NMDA) receptors. The NMDAreceptor is highly permeable to calcium ions and plays a key role in theplasticity of synapses.hich is believed to underlie memory and learning.s well as the development of the nervous system. Abnormal activation hasbeen suggested to lead to neuronal cell death observed in many acute andchronic disorders such as ischemia.troke.lzheimers disease.ndHuntingdons disease .NMDA receptors possess 4 transmembrane (TM) helical domains in the C-terminal half of the sequence and require both glycine and glutamate foractivation.esulting in influx of calcium ions into the cell . Thereceptors can also be activated by polyamine.hey can be blocked bymagnesium ions.nhibited by zinc ions.nd modulated by arachidonic acid.Other non-NMDA glutamate receptors (e.g..ainate) are structurally similarto NMDA receptors.ut are functionally distinct.ossibly as a result ofamino acid substitutions at important positions in the sequence.
  IPR001508:NMDA receptor
IPR001320:Lig_chan 
Evalue:-98.6197891235352 
Location:582-866IPR001828:ANF_receptor 
Evalue:-5.04575729370117 
Location:62-394
SequencesProtein: NMDE4_HUMAN (1336 aa)
mRNA: NM_000836
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
Either stimulating afferents at high frequency or by directly depolarizing the postsynaptic cell with current injection leads to the Magnalium leaving the AMDAR, then calium and sodium enter the postsynaptic cell and trigger for LTP
sdb:0248 NMDA receptor-dependent LTP  (Evidence:keywords,domains)
?
sdb:0263 presynaptic LTP  (Evidence:keywords,domains)
?
sdb:0297 NMDA receptor  (Evidence:keywords,domains)
KO assignmentK05212
  Level 3 annotation:
    glutamate receptor, ionotropic, N-methyl D-aspartate 2D
  Level 2 annotation:
    Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Ion channels
    Long-term potentiation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 21 residues, 53589943-53590005Exon2: 165 residues, 53593435-53593926Exon3: 208 residues, 53599802-53600422Exon4: 40 residues, 53609059-53609174Exon5: 72 residues, 53609441-53609653Exon6: 58 residues, 53609932-53610101Exon7: 53 residues, 53611070-53611224Exon8: 44 residues, 53614302-53614428Exon9: 78 residues, 53614653-53614883Exon10: 55 residues, 53616853-53617014Exon11: 64 residues, 53636837-53637025Exon12: 79 residues, 53637218-53637451Exon13: 514 residues, 53637668-53639205Exon14: 2 residues, -Jump to NMDE4_HUMAN  
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Loci Cluster (Details)Loci: 3124 53589943-53639205 ~-49K 19224(GRIN2D)(+)Loci: 3125 53656317-53661179 ~-5K 19226(KCNJ14)(+)Loci: 3126 53747240-53794495 ~-47K 19229(SULT2B1)(+)Loci: 4406 53833083-53841263 ~-8K 19240(CA11)(-)Loci: 4407 53990131-54006113 ~-16K 19255(BCAT2)(-)Loci: 4408 54262487-54268010 ~-6K 19284(-)Loci: 3127 54309429-54313528 ~-4K 19290(LIN7B)(+)Loci: 3128 54314474-54346090 ~-32K 19292(PPFIA3)(+)Loci: 4409 54484705-54520286 ~-36K 19297(SLC6A16)(-)Loci: 3129 54669297-54681299 ~-12K 19311(FLT3LG)(+)Loci: 4410 54854641-54860926 ~-6K 19323(IRF3)(-)Loci: 3130 54886218-54908800 ~-23K 19334(CPT1C)(+)Loci: 3131 54961991-55002179 ~-40K 19337(AP2A1)(+)Loci: 3132 55124271-55129003 ~-5K 19355(ATF5)(+)Loci: 4411 55510576-55524446 ~-14K 19365(KCNC3)(-)Loci: 4412 55817047-55833114 ~-16K 19382(SYT3)(-)Loci: 4413 55856895-55912007 ~-55K 19383(SHANK1)(-)Loci: 3123 53559468-53571439 ~-12K 19220(SYNGR4)(+)Link out to UCSC