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0NMDE3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionGlutamate receptor subunit epsilon 3 precursor (n-methyl d- aspartate receptor subtype 2c) (nr2c) (nmdar2c).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004972 N-methyl-D-aspartate selective glutamate re... (TAS)
0007215 glutamate signaling pathway (TAS)
0006810 transport (TAS)

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Domain Architecture (Details)
InterPro domains assigned to SynO:
The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are three classes of ionotropic glutamate receptor.amely NMDA (N-methyl-D-aspartate).MPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionicacid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain.ransient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission .
  IPR001320:Ionotropic glutamate receptor
InterPro domains unassigned to SynO:
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
N-Methyl-D-aspartate (NMDA) receptors are members of the glutamate receptorchannel superfamily.hich mediate most of the fast excitory synaptictransmissions in the central nervous system. The superfamily consists of 3subtypes: kainate receptors.lpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors and N-methyl-D-aspartate (NMDA) receptors. The NMDAreceptor is highly permeable to calcium ions and plays a key role in theplasticity of synapses.hich is believed to underlie memory and learning.s well as the development of the nervous system. Abnormal activation hasbeen suggested to lead to neuronal cell death observed in many acute andchronic disorders such as ischemia.troke.lzheimers disease.ndHuntingdons disease .NMDA receptors possess 4 transmembrane (TM) helical domains in the C-terminal half of the sequence and require both glycine and glutamate foractivation.esulting in influx of calcium ions into the cell . Thereceptors can also be activated by polyamine.hey can be blocked bymagnesium ions.nhibited by zinc ions.nd modulated by arachidonic acid.Other non-NMDA glutamate receptors (e.g..ainate) are structurally similarto NMDA receptors.ut are functionally distinct.ossibly as a result ofamino acid substitutions at important positions in the sequence.
  IPR001508:NMDA receptor
SequencesProtein: NMDE3_HUMAN (1233 aa)
mRNA: NM_000835
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
Either stimulating afferents at high frequency or by directly depolarizing the postsynaptic cell with current injection leads to the Magnalium leaving the AMDAR, then calium and sodium enter the postsynaptic cell and trigger for LTP
sdb:0248 NMDA receptor-dependent LTP  (Evidence:keywords,domains)
sdb:0263 presynaptic LTP  (Evidence:keywords,domains)
sdb:0297 NMDA receptor  (Evidence:keywords,domains)
KO assignmentK05211
  Level 3 annotation:
    glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  Level 2 annotation:
    Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Ion channels
    Long-term potentiation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 509 residues, 70349762-70351287Exon2: 79 residues, 70352009-70352242Exon3: 64 residues, 70353799-70353987Exon4: 55 residues, 70354493-70354654Exon5: 78 residues, 70355041-70355271Exon6: 44 residues, 70355585-70355711Exon7: 53 residues, 70357513-70357667Exon8: 57 residues, 70357939-70358105Exon9: 72 residues, 70358289-70358501Exon10: 40 residues, 70359310-70359425Exon11: 201 residues, 70359746-70360345Exon12: 140 residues, 70362427-70362841Exon13: 49 residues, 70367461-70367602Exon14: 2 residues, -Jump to NMDE3_HUMAN  
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Loci Cluster (Details)Loci: 3038 70178864-70255068 ~-76K 16552(+)Loci: 3039 70256378-70277089 ~-21K 16559(SLC9A3R1)(+)Loci: 4310 70349762-70367602 ~-18K 16565(GRIN2C)(-)Loci: 4311 70370220-70380710 ~-10K 16567(FDXR)(-)Loci: 4312 70546549-70554669 ~-8K 16577(ATP5H)(-)Loci: 4313 70637918-70639472 ~-2K 16582(NT5C)(-)Loci: 4314 70744289-70769272 ~-25K 16589(GGA3)(-)Loci: 4315 70780668-70797109 ~-16K 16594(SLC25A19)(-)Loci: 4316 71265612-71272875 ~-7K 16620(GALK1)(-)Loci: 4317 71514521-71534972 ~-20K 16639(EVPL)(-)Loci: 4318 71546785-71580202 ~-33K 16642(SRP68)(-)Loci: 3040 71582486-71585168 ~-3K 16644(GALR2)(+)Loci: 3041 71586857-71590480 ~-4K 16645(+)Loci: 4319 71588681-71611451 ~-23K 16647(EXOC7)(-)Loci: 3037 69833964-69859062 ~-25K 16537(+)Link out to UCSC