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0NLTP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSCP2
DescriptionNonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005777 peroxisome (TAS)
0005498 sterol carrier activity (TAS)
0006694 steroid biosynthesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is involved in binding sterols. The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids . The unc-24 protein of Caenorhabditis elegans contains a domain similar to part of two ion channel regulators (the erythrocyte integral membrane protein stomatin and the C. elegans neuronal protein MEC-2) juxtaposed to a domain similar to nonspecific lipid transfer protein (nsLTP; also called sterol carrier protein 2) .
  IPR003033:Sterol-binding
Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase () and 3-ketoacyl-CoA thiolase (). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or steroid biogenesis.In eukaryotes.here are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes.There are two conserved cysteine residues important for thiolase activity. The first located in the N-terminal section of the enzymes is involved in the formation of an acyl-enzyme intermediate; the second located at the C-terminal extremity is the active site base involved in deprotonation in the condensation reaction.Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). The former is found in the cytoplasm or the mitochondria and is involved in lipid transport; the latter is found in peroxisomes. The C-terminal part of SCP-x is identical to SCP-2 while the N-terminal portion is evolutionary related to thiolases .
  IPR002155:Thiolase
Glucose dehydrogenase catalyses the oxidation of D-glucose without priorphosphorylation to D-beta-gluconolactone using NAD or NADP as a coenzyme.The enzyme is a tetrameric protein.ach of the 4 identical subunitscontaining 262 amino acid residues. This family is a subset of a more general family of short-chain dehydrogenases andreductases.A match to this extension indicates that the protein is notan alcohol dehydrogenase.ut another type of dehydrogenaseor reductase.
  IPR002347:Glucose/ribitol dehydrogenase
IPR003033:SCP2 
Evalue:-48.5686378479004 
Location:433-543IPR002155:Thiolase_C 
Evalue:-9.76955127716064 
Location:284-361IPR002155:Thiolase_N 
Evalue:-5.24412536621094 
Location:11-240IPR002155:THIOLASE_3 
Evalue:0 
Location:0-0
SequencesProtein: NLTP_HUMAN (547 aa)
mRNA: NM_002979
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 64 residues, 53165535-53165725Exon2: 21 residues, 53180055-53180113Exon3: 26 residues, 53186268-53186340Exon4: 46 residues, 53189014-53189146Exon5: 23 residues, 53192999-53193064Exon6: 44 residues, 53199762-53199889Exon7: 23 residues, 53213028-53213092Exon8: 31 residues, 53214942-53215029Exon9: 52 residues, 53216476-53216627Exon10: 51 residues, 53218655-53218803Exon11: 38 residues, 53226288-53226396Exon12: 53 residues, 53253149-53253303Exon13: 36 residues, 53266228-53266331Exon14: 45 residues, 53277176-53277306Exon15: 28 residues, 53286117-53286197Exon16: 336 residues, 53288868-53289870Exon17: 2 residues, -Jump to NLTP_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2519 53434688-53452455 ~-18K 1515(CPT2)(+)Loci: 3804 53483804-53566314 ~-83K 1520(LRP8)(-)Loci: 2518 53165535-53289870 ~-124K 1506(SCP2)(+)Link out to UCSC