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0NLGN2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionNeuroligin-2 precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0045211 postsynaptic membrane (NAS)
0042043 neurexin binding (NAS)
0016337 cell-cell adhesion (NAS)
0045217 intercellular junction maintenance (NAS)
0007416 synaptogenesis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Higher eukaryotes have many distinct esterases. Among the different types arethose which act on carboxylic esters (). Carboxyl-esterases havebeen classified into three categories (A. and C) on the basis ofdifferential patterns of inhibition by organophosphates. The sequence of anumber of type-B carboxylesterases indicates that the majority are evolutionary related. As is the case for lipases and serine proteases.he catalytic apparatus ofesterases involves three residues (catalytic triad): a serine. glutamate oraspartate and a histidine.
  IPR002018:Carboxylesterase, type B
Neuroligins constitute a family of brain neurone-specific membrane proteinswhose structural and biochemical characteristics are indicative of a role inheterotypic cell adhesion . Functionally.hey bind to the extracellulardomains of a subset of beta-neurexins in a Ca2+-dependent manner. They havebeen localised to the postsynaptic membranes of excitatory synapses .This.ogether with the fact that their C-termini likely bind to PSD-95 (aPDZ-domain protein enriched in postsynaptic densities).uggests that theymay be involved in the recruitment of proteins (such as receptors.onchannels and signal-transduction molecules) to synaptic sites of celladhesion.To date.hree neuroligins have been reported.esignated neuroligin 1-3 .Multiple sequence alignment has revealed them to be highly similar.haringoverall ~52% identity. The similarity is distributed over the whole proteinsequence.ith the extracellular and transmembrane (TM) domains being moreconserved than the cytoplasmic regions. They are composed of five domains:an N-terminal cleaved signal sequence; a large extracellular region homologous to esterases; a linker between the TM domain and the esterase homology domain that may be O-glycosylated; a single TM domain; and acytoplasmic C-terminal tail. Further sequence comparisons place theneuroligins into the large family of esterase homology domain proteins.hich includes thyroglobulin.cetylcholinesterase.nd gliotactin.lthough the neuroligins are themselves catalytically inactive.
SequencesProtein: NLGN2_HUMAN (835 aa)
mRNA: NM_020795
Local Annotation
Synapse Ontology
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentK07378
  Level 3 annotation:
  Level 2 annotation:
    Cell adhesion molecules (CAMs)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 177 residues, 7252225-7252755Exon2: 19 residues, 7256199-7256250Exon3: 52 residues, 7258386-7258536Exon4: 64 residues, 7258705-7258891Exon5: 66 residues, 7258998-7259191Exon6: 201 residues, 7259553-7260150Exon7: 980 residues, 7260968-7263903Exon8: 2 residues, -Jump to NLGN2_HUMAN  
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Loci Cluster (Details)Loci: 4258 6644024-6675784 ~-32K 14997(TEKT1)(-)Loci: 4259 7033935-7063745 ~-30K 15014(DLG4)(-)Loci: 2974 7063876-7069308 ~-5K 15016(ACADVL)(+)Loci: 4260 7084462-7086477 ~-2K 15021(GABARAP)(-)Loci: 2975 7252225-7263903 ~-12K 15047(NLGN2)(+)Loci: 2976 7289129-7301655 ~-13K 15051(CHRNB1)(+)Loci: 2977 7427889-7432228 ~-4K 15066(MPDU1)(+)Loci: 2978 7474184-7477419 ~-3K 15071(SHBG)(+)Loci: 4261 7512446-7531642 ~-19K 15074(TP53)(-)Loci: 4262 7774391-7775983 ~-2K 15094(TRAPPC1)(-)Loci: 2979 7846716-7864382 ~-18K 15097(GUCY2D)(+)Loci: 4263 8004447-8006987 ~-3K 15108(VAMP2)(-)Loci: 2980 8093361-8114528 ~-21K 15119(PFAS)(+)Loci: 2981 8279988-8330396 ~-50K 15135(+)Loci: 2973 6620295-6631688 ~-11K 14996(FBXO39)(+)Link out to UCSC