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0NLGN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNLGN1
DescriptionNeuroligin-1 precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (ISS)
0045202 synapse (ISS)
0016789 carboxylic ester hydrolase activity (ISS)
0042043 neurexin binding (ISS)
0016339 calcium-dependent cell-cell adhesion (ISS)
0045161 neuronal ion channel clustering (ISS)
0006605 protein targeting (ISS)
0045664 regulation of neuron differentiation (ISS)
0016080 synaptic vesicle targeting (ISS)
0007416 synaptogenesis (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Higher eukaryotes have many distinct esterases. Among the different types arethose which act on carboxylic esters (). Carboxyl-esterases havebeen classified into three categories (A. and C) on the basis ofdifferential patterns of inhibition by organophosphates. The sequence of anumber of type-B carboxylesterases indicates that the majority are evolutionary related. As is the case for lipases and serine proteases.he catalytic apparatus ofesterases involves three residues (catalytic triad): a serine. glutamate oraspartate and a histidine.
  IPR002018:Carboxylesterase, type B
Neuroligins constitute a family of brain neurone-specific membrane proteinswhose structural and biochemical characteristics are indicative of a role inheterotypic cell adhesion . Functionally.hey bind to the extracellulardomains of a subset of beta-neurexins in a Ca2+-dependent manner. They havebeen localised to the postsynaptic membranes of excitatory synapses .This.ogether with the fact that their C-termini likely bind to PSD-95 (aPDZ-domain protein enriched in postsynaptic densities).uggests that theymay be involved in the recruitment of proteins (such as receptors.onchannels and signal-transduction molecules) to synaptic sites of celladhesion.To date.hree neuroligins have been reported.esignated neuroligin 1-3 .Multiple sequence alignment has revealed them to be highly similar.haringoverall ~52% identity. The similarity is distributed over the whole proteinsequence.ith the extracellular and transmembrane (TM) domains being moreconserved than the cytoplasmic regions. They are composed of five domains:an N-terminal cleaved signal sequence; a large extracellular region homologous to esterases; a linker between the TM domain and the esterase homology domain that may be O-glycosylated; a single TM domain; and acytoplasmic C-terminal tail. Further sequence comparisons place theneuroligins into the large family of esterase homology domain proteins.hich includes thyroglobulin.cetylcholinesterase.nd gliotactin.lthough the neuroligins are themselves catalytically inactive.
  IPR000460:Neuroligin
IPR002018:COesterase 
Evalue:-210.036209106445 
Location:33-623IPR000460:NEUROLIGIN 
Evalue:0 
Location:687-716
SequencesProtein: NLGN1_HUMAN (840 aa)
mRNA: NM_014932
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK07378
  Level 3 annotation:
    neuroligin
  Level 2 annotation:
    Cell adhesion molecules (CAMs)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 12 residues, 174598937-174598971Exon2: 25 residues, 174635493-174635562Exon3: 273 residues, 174804762-174805575Exon4: 53 residues, 175008163-175008316Exon5: 73 residues, 175475798-175476011Exon6: 265 residues, 175479344-175480134Exon7: 950 residues, 175480964-175483810Exon8: 2 residues, -Jump to NLGN1_HUMAN