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0NK2R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTACR2
DescriptionSubstance-k receptor (skr) (neurokinin a receptor) (nk-2 receptor) (nk-2r) (tachykinin receptor 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004995 tachykinin receptor activity (TAS)
0007588 excretion (TAS)
0006936 muscle contraction (TAS)
0007217 tachykinin signaling pathway (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide receptors are present in very small quantities in the celland are embedded tightly in the plasma membrane. The neuropeptides exhibita high degree of functional diversity through both regulation of peptideproduction and through peptide-receptor interaction . The mammaliantachykinin system consists of 3 distinct peptides: substance P.ubstanceK and neuromedin K. All possess a common spectrum of biological activities.ncluding sensory transmission in the nervous system and contraction/relaxation of peripheral smooth muscles.nd each interacts with aspecific receptor type.In the periphery.K2 receptors are found in smooth muscle of therespiratory.astrointestinal and urogenital systems. NK2 receptorsactivate the phosphoinositide pathway through a pertussis-toxin-insensitiveG-protein.robably of the Gq/G11 class .
  IPR000913:Neurokinin NK2 receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide receptors are present in very small quantities in the celland are embedded tightly in the plasma membrane. The neuropeptides exhibita high degree of functional diversity through both regulation of peptideproduction and through peptide-receptor interaction . The mammaliantachykinin system consists of 3 distinct peptides: substance P.ubstanceK and neuromedin K. All possess a common spectrum of biological activities.ncluding sensory transmission in the nervous system and contraction/relaxation of peripheral smooth muscles.nd each interacts with aspecific receptor type.
  IPR001681:Neurokinin receptor
IPR000276:7tm_1 
Evalue:-80.6382751464844 
Location:50-307IPR000913:NEUROKININ2R 
Evalue:0 
Location:326-345IPR000913:NEUROKININ2R 
Evalue:0 
Location:359-377IPR000913:NEUROKININ2R 
Evalue:0 
Location:15-28IPR001681:NEUROKININR 
Evalue:0 
Location:29-40
SequencesProtein: NK2R_HUMAN (398 aa)
mRNA: BC033742
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04223
  Level 3 annotation:
    tachykinin receptor 2 (Substance K)
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 200 residues, 70834248-70834846Exon2: 67 residues, 70836845-70837042Exon3: 53 residues, 70838683-70838837Exon4: 67 residues, 70844706-70844901Exon5: 306 residues, 70845693-70846607Exon6: 2 residues, -Jump to NK2R_HUMAN  
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Loci Cluster (Details)Loci: 2622 70748628-70831641 ~-83K 5039(HK1)(+)Loci: 3897 70834248-70846607 ~-12K 5040(TACR2)(-)Loci: 2621 70553913-70602620 ~-49K 5030(VPS26)(+)Link out to UCSC