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0NK1R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTACR1
DescriptionSubstance-p receptor (spr) (nk-1 receptor) (nk-1r) (tachykinin receptor 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004995 tachykinin receptor activity (TAS)
0009582 detection of abiotic stimulus (TAS)
0007200 G-protein signaling, coupled to IP3 second ... (TAS)
0006954 inflammatory response (TAS)
0007638 mechanosensory behavior (TAS)
0007217 tachykinin signaling pathway (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide receptors are present in very small quantities in the celland are embedded tightly in the plasma membrane. The neuropeptides exhibita high degree of functional diversity through both regulation of peptideproduction and through peptide-receptor interaction . The mammaliantachykinin system consists of 3 distinct peptides: substance P.ubstanceK and neuromedin K. All possess a common spectrum of biological activities.ncluding sensory transmission in the nervous system and contraction/relaxation of peripheral smooth muscles.nd each interacts with aspecific receptor type.In the brain.igh concentrations of the NK1 receptor are found in striatum.lfactory bulb.endate gyrus.ocus coeruleus and spinal chord . Inperipheral tissues NK1 receptors are found in smooth muscle (e.g..leumand bladder).nteric neurons.ecretory glands (e.g. parotid).ells ofthe immune system and vascular endothelium. NK1 receptors activate thephosphoinositide pathway through a pertussis-toxin-insensitive G-protein .
  IPR000046:Neurokinin NK1 receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide receptors are present in very small quantities in the celland are embedded tightly in the plasma membrane. The neuropeptides exhibita high degree of functional diversity through both regulation of peptideproduction and through peptide-receptor interaction . The mammaliantachykinin system consists of 3 distinct peptides: substance P.ubstanceK and neuromedin K. All possess a common spectrum of biological activities.ncluding sensory transmission in the nervous system and contraction/relaxation of peripheral smooth muscles.nd each interacts with aspecific receptor type.
  IPR001681:Neurokinin receptor
IPR000276:7tm_1 
Evalue:-93.1804580688477 
Location:49-305IPR001681:NEUROKININR 
Evalue:0 
Location:306-324IPR000046:NEUROKININ1R 
Evalue:0 
Location:360-377IPR000046:NEUROKININ1R 
Evalue:0 
Location:390-406IPR000046:NEUROKININ1R 
Evalue:0 
Location:13-25IPR001681:NEUROKININR 
Evalue:0 
Location:28-39
SequencesProtein: NK1R_HUMAN (407 aa)
mRNA: NM_001058
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04222
  Level 3 annotation:
    tachykinin receptor 1 (Substance P)
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 208 residues, 75129737-75130358Exon2: 67 residues, 75131885-75132082Exon3: 52 residues, 75134239-75134390Exon4: 67 residues, 75201207-75201402Exon5: 202 residues, 75279179-75279781Exon6: 2 residues, -Jump to NK1R_HUMAN  
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