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0NIT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNIT1
DescriptionNitrilase homolog 1 (ec 3.5.-.-).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000257 nitrilase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family contains nitrilases that break carbon-nitrogen bonds and appear to be involved in the reduction of organic nitrogen compounds and ammonia production . They all have distinct substrate specificity and include cyanide hydratases.liphatic amidases.eta-alanine synthase.nd a few other proteins with unknown molecular function. Sequence conservation over the entire length.s well as the similarity in the reactions catalyzed by the known enzymes in this family.oints to a common catalytic mechanism. They have an invariant cysteine that is part of the catalytic site in nitrilases. Another highly conserved motif includes an invariant glutamic acid that might also be involved in catalysis .
  IPR003010:Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase
IPR003010:CN_hydrolase 
Evalue:-62.2146682739258 
Location:48-228
SequencesProtein: NIT1_HUMAN (327 aa)
mRNA: NM_005600
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK01506
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 27 residues, 159354514-159354592Exon2: 34 residues, 159355199-159355295Exon3: 87 residues, 159355547-159355802Exon4: 36 residues, 159355922-159356026Exon5: 46 residues, 159356232-159356366Exon6: 44 residues, 159356520-159356646Exon7: 191 residues, 159356912-159357481Exon8: 2 residues, -Jump to NIT1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2566 159402817-159407634 ~-5K 3130(PPOX)(+)Loci: 3843 159407724-159413938 ~-6K 3131(B4GALT3)(-)Loci: 2567 159435728-159450806 ~-15K 3135(NDUFS2)(+)Loci: 3844 159458706-159460042 ~-1K 3139(APOA2)(-)Loci: 3845 159541150-159546368 ~-5K 3155(MPZ)(-)Loci: 2568 159550789-159601157 ~-50K 3157(SDHC)(+)Loci: 2565 159354514-159357481 ~-3K 3121(NIT1)(+)Link out to UCSC