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0NIPBL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNIPBL
DescriptionNipped-b-like protein (delangin) (scc2 homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain was first thought to represent apidaecins.ut has now been found in a variety of cell surface proteins. It is found in PAC protein. cell surface antigen implicated in dental caries; cell surface antigens SpaA and SpaP; IGA FC receptor.lso known as beta antigen; and agglutinin receptor.
  IPR004829:Cell surface antigen
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR011989:ARM-like 
Evalue:0 
Location:1839-2227IPR011989:ARM-like 
Evalue:0 
Location:1538-1838IPR004829:Csurface_antigen 
Evalue:0 
Location:701-758IPR000357:HEAT_REPEAT 
Evalue:0 
Location:0-0
SequencesProtein: NIPBL_HUMAN (2804 aa)
mRNA: NM_133433
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 99 residues, 36912741-36913037Exon2: 49 residues, 36989476-36989619Exon3: 57 residues, 36991330-36991496Exon4: 44 residues, 36993962-36994090Exon5: 35 residues, 36997342-36997442Exon6: 52 residues, 36997981-36998133Exon7: 55 residues, 37006734-37006895Exon8: 34 residues, 37007803-37007900Exon9: 211 residues, 37011634-37012261Exon10: 544 residues, 37020534-37022160Exon11: 63 residues, 37031480-37031663Exon12: 68 residues, 37036231-37036429Exon13: 26 residues, 37036675-37036747Exon14: 32 residues, 37036847-37036937Exon15: 36 residues, 37038520-37038624Exon16: 31 residues, 37039119-37039206Exon17: 79 residues, 37042215-37042447Exon18: 52 residues, 37043181-37043333Exon19: 29 residues, 37043866-37043947Exon20: 35 residues, 37044481-37044582Exon21: 48 residues, 37045945-37046084Exon22: 29 residues, 37050541-37050624Exon23: 46 residues, 37051896-37052029Exon24: 50 residues, 37052877-37053021Exon25: 32 residues, 37055169-37055259Exon26: 73 residues, 37056317-37056532Exon27: 36 residues, 37056633-37056736Exon28: 35 residues, 37057909-37058008Exon29: 51 residues, 37058102-37058249Exon30: 47 residues, 37060443-37060578Exon31: 35 residues, 37062087-37062186Exon32: 20 residues, 37063217-37063271Exon33: 38 residues, 37072237-37072346Exon34: 47 residues, 37074460-37074597Exon35: 49 residues, 37080205-37080346Exon36: 33 residues, 37080494-37080588Exon37: 53 residues, 37081301-37081456Exon38: 32 residues, 37081967-37082058Exon39: 60 residues, 37084360-37084534Exon40: 65 residues, 37084969-37085160Exon41: 38 residues, 37087637-37087745Exon42: 69 residues, 37088224-37088425Exon43: 51 residues, 37093044-37093191Exon44: 93 residues, 37094749-37095024Exon45: 60 residues, 37096702-37096877Exon46: 65 residues, 37099648-37099837Exon47: 432 residues, 37100385-37101677Exon48: 2 residues, -Jump to NIPBL_HUMAN  
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Loci Cluster (Details)Loci: 3449 36912741-37101677 ~-189K 28716(NIPBL)(+)Loci: 3448 36642447-36724191 ~-82K 28713(SLC1A3)(+)Link out to UCSC