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0NIFUN_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNIFUN
DescriptionNifu-like n-terminal domain containing protein, mitochondrial precursor (nifu-like protein) (iron-sulfur cluster assembly enzyme iscu).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (IDA)
0005506 iron ion binding (TAS)
0016226 iron-sulfur cluster assembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Pioneering investigations on the maturation of Fe-S proteins were performed in bacteria and have led to the identification of two operons termed nif (nitrogen fixation) and isc (iron-sulfur cluster assembly) that function in Fe-S-cluster biosynthesis. The nif operon encodes proteins that execute specific functions in the assembly of nitrogenase. complex metalloenzyme that catalyses the fixation of nitrogen; some of the Nif proteins are specifically involved in the formation of the Fe-S cluster of nitrogenase and these are found in organisms that do not fix nitrogen . The isc operon encodes proteins necessary for the maturation of bacterial Fe-S proteins. In a number of organisms.or example Azotobacter vinelandii.ifU is a protein associated with the nif operon. It contains two domains.he N-terminal.resented in this entry.nd the C-terminal (). These domains exist either together or on different polypeptides.oth domains being found in organisms that do not fix nitrogen e.g. yeast.o they have a broader significance in the cell than nitrogen fixation. It has been proposed that they are specifically required for the formation and maturation of Fe-S clusters that in eukaryotes occurs in the mitochondrial matrix. In yeast.or example.eletion of the C-terminal domain does not markedly affect Fe-S biosynthesis but in combination with inactivation of ISU1 there is a defect in mitochondrial FE-S-protein maturation.
  IPR002871:Nitrogen-fixing NifU-like, N-terminal
This entry represents IscU. homologue of the N-terminal region of NifU.n Fe-S cluster assembly protein found mostly in nitrogen-fixing bacteria. IscU is considered part of the IscSUA-hscAB-fdx system of Fe-S assembly.hereas NifU is found in nitrogenase-containing (nitrogen-fixing) species. IscU and NifU are considered scaffold proteins on which Fe-S clusters are assembled before transfer to apoproteins. This family includes largely proteobacterial and eukaryotic forms and excludes the true NifU proteins from Klebsiella pneumoniae and Anabaena sp. as well as the archaeal homologues.
  IPR011339:FeS cluster assembly scaffold IscU
IPR002871:NifU_N 
Evalue:-80.236572265625 
Location:34-160
SequencesProtein: NIFUN_HUMAN (167 aa)
mRNA: AY009127
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 44 residues, 107480511-107480641Exon2: 34 residues, 107481964-107482060Exon3: 40 residues, 107482183-107482297Exon4: 39 residues, 107483225-107483336Exon5: 28 residues, 107485094-107485173Exon6: 34 residues, 107486735-107486831Exon7: 146 residues, 107486840-107487272Exon8: 2 residues, -Jump to NIFUN_HUMAN  
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