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0NHRF2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC9A3R2
DescriptionNa(+)/h(+) exchange regulatory cofactor nhe-rf2 (nherf-2) (tyrosine kinase activator protein 1) (tka-1) (sry interacting protein 1) (sip- 1) (solute carrier family 9 isoform a3 regulatory factor 2) (nhe3 kinase a regulatory protein e3karp) (sodium-hydrogen exchanger regulatory factor 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0005886 plasma membrane (TAS)
0005515 protein binding (IPI)
0007242 intracellular signaling cascade (NAS)
0006461 protein complex assembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
IPR001478:PDZ 
Evalue:-20.2518119729938 
Location:19-91IPR001478:PDZ 
Evalue:-19.4948500216801 
Location:159-231
SequencesProtein: NHRF2_HUMAN (337 aa)
mRNA: BC014513 NM_004785
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 109 residues, 2016896-2017220Exon2: 69 residues, 2019583-2019784Exon3: 62 residues, 2026325-2026505Exon4: 53 residues, 2026729-2026883Exon5: 16 residues, 2026956-2027000Exon6: 23 residues, 2027539-2027602Exon7: 220 residues, 2027827-2028481Exon8: 2 residues, -Jump to NHRF2_HUMANExon1: 98 residues, 2016929-2017220Exon2: 69 residues, 2019583-2019784Exon3: 62 residues, 2026325-2026505Exon4: 53 residues, 2026729-2026883Exon5: 16 residues, 2026956-2027000Exon6: 23 residues, 2027539-2027602Exon7: 210 residues, 2027860-2028484Exon8: 2 residues, -Jump to NHRF2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2909 387192-390754 ~-4K 13162(NME4)(+)Loci: 2910 415668-512481 ~-97K 13166(RAB11FIP3)(+)Loci: 2911 580179-619272 ~-39K 13173(RAB40C)(+)Loci: 4199 774975-778384 ~-3K 13216(-)Loci: 2912 1143241-1211772 ~-69K 13223(CACNA1H)(+)Loci: 2913 1324663-1339443 ~-15K 13234(BAIAP3)(+)Loci: 4200 1435345-1465013 ~-30K 13244(CLCN7)(-)Loci: 2914 1696221-1760318 ~-64K 13253(MAPK8IP3)(+)Loci: 2915 1979968-1984276 ~-4K 13288(SYNGR3)(+)Loci: 2916 2016896-2028484 ~-12K 13290(SLC9A3R2)(+)Loci: 2917 2038599-2078713 ~-40K 13294(TSC2)(+)Loci: 2918 2138651-2144141 ~-5K 13300(RAB26)(+)Loci: 4201 2167184-2186466 ~-19K 13303(CASKIN1)(-)Loci: 4198 357394-360541 ~-3K 13159(MRPL28)(-)Link out to UCSC