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0NHLC1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNHLRC1
DescriptionNhl repeat containing protein 1 (malin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Quality control of intracellular proteins is essential for cellular homeostasis. Molecular chaperones recognise and contribute to the refolding of misfolded or unfolded proteins.hereas the ubiquitin-proteasome system mediates the degradation of such abnormal proteins. Ubiquitin-protein ligases (E3s) determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. More recently.owever.-box proteins.hich contain a domain (the U box) of about 70 amino acids that is conserved from yeast to humans.ave been identified as a new type of E3 .The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc.nd is probably involved in mediating protein-protein interactions. . There are two different variants.he C3HC4-type and a C3H2C3-type.hich is clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as RING-H2 finger. The RING domain is a protein interaction domain which has been implicated in a range of diverse biological processes.E3 ubiquitin-protein ligase activity is intrinsic to the RING domain ofc-Cbl and is likely to be a general function of this domain; Various RINGfingers exhibit binding to E2 ubiquitin-conjugating enzymes (Ubcs) .Several 3D-structures for RING-fingers are known . The 3D structure of the zinc ligation system is unique to the RING domain and is referred to as the cross-brace motif. The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion.hilst pairs two and four bind the second.s illustrated in the following schematic representation:Note that in the older literature.ome RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family.lbeit with similar Cys-spacing (see ).
  IPR001841:Zinc finger, RING-type
The NHL (NCL-1.T2A and LIN-41) repeat is found in a variety of enzymes of the copper type II.scorbate-dependent monooxygenase family which catalyse the C-terminus alpha-amidation of biological peptides . The repeat also occurs in a human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins . The repeat domain that is often associated with RING finger and B-box motifs .
  IPR001258:NHL repeat
IPR001841:RING 
Evalue:-5.0087739243075 
Location:26-71IPR001258:NHL 
Evalue:-1.88605666160583 
Location:363-390IPR001258:NHL 
Evalue:-1.52287876605988 
Location:174-201IPR001258:NHL 
Evalue:-1.48148608207703 
Location:126-154IPR001258:NHL 
Evalue:-0.698970019817352 
Location:215-242IPR001258:NHL 
Evalue:-0.327902138233185 
Location:261-297IPR013017:NHL 
Evalue:0 
Location:301-349
SequencesProtein: NHLC1_HUMAN (395 aa)
mRNA: NM_198586
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 712 residues, 18228696-18230830Exon2: 2 residues, -Jump to NHLC1_HUMAN  
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Loci Cluster (Details)Loci: 4773 18228696-18230830 ~-2K 30372(NHLRC1)(-)Loci: 4772 17871904-18095692 ~-224K 30367(KIF13A)(-)Link out to UCSC