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0NFS1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNFS1
DescriptionCysteine desulfurase, mitochondrial precursor (ec 2.8.1.7).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005829 cytosol (TAS)
0005739 mitochondrion (TAS)
0005634 nucleus (TAS)
0006461 protein complex assembly (TAS)
0000096 sulfur amino acid metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes.uch as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity.hese various enzymes can be grouped into subfamilies.This family is called class-V.
  IPR000192:Aminotransferase, class V
IPR000192:Aminotran_5 
Evalue:-126.552841186523 
Location:59-422
SequencesProtein: NFS1_HUMAN (457 aa)
mRNA: NM_021100
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK04487
  Level 3 annotation:
    cysteine desulfurase
  Level 2 annotation:
    Other amino acid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 333 residues, 33720024-33721021Exon2: 32 residues, 33724090-33724180Exon3: 30 residues, 33724936-33725020Exon4: 29 residues, 33725685-33725767Exon5: 37 residues, 33725847-33725953Exon6: 54 residues, 33726380-33726538Exon7: 47 residues, 33732072-33732207Exon8: 33 residues, 33733223-33733317Exon9: 53 residues, 33741748-33741901Exon10: 30 residues, 33747712-33747796Exon11: 41 residues, 33749019-33749136Exon12: 38 residues, 33749816-33749926Exon13: 55 residues, 33750527-33750688Exon14: 2 residues, -Jump to NFS1_HUMAN  
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Loci Cluster (Details)Loci: 4520 33754944-33793607 ~-39K 23005(RNPC2)(-)Loci: 4519 33720024-33750688 ~-31K 22998(NFS1)(-)Link out to UCSC