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0NFAC2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNFATC2
DescriptionNuclear factor of activated t-cells, cytoplasmic 2 (t cell transcription factor nfat1) (nfat pre-existing subunit) (nf-atp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005634 nucleus (TAS)
0003700 transcription factor activity (TAS)
0006355 regulation of transcription, DNA-dependent (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding.The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation.otility.nd invasion of extracellular matrices (scattering) .
  IPR002909:Cell surface receptor IPT/TIG
Antigenic stimulation of T lymphocytes initiates a complex series ofintracellular signal transduction pathways that leads to the expression of apanel of immunoregulatory genes.hose function is critical to theinitiation and coordination of the immune response. The multi-subunitnuclear factor of activated T cells (NFAT) transcription factor familyplays a pivotal role in this process and is involved in the expression of anumber of immunologically important genes. These include the cytokines IL-2.L-3.L-4.L-5.ranulocyte-macrophage colony-stimulating factor.ndtumour necrosis factor-alpha.s well as several cell-surface molecules.uch as CD40L and FasL. Although originally described in T cells.t is nowapparent that NFAT proteins are also expressed in other immune system cells.ncluding B cells.ast cells.asophils and natural killer cells.s wellas in a variety of non-immune cell types and tissues.uch as skeletalmuscle.eurons.eart and adipocytes. However.lthough NFAT acts as acalcium-dependent transcription factor and serves to couple gene expressionto changes in intracellular calcium levels in most cases.FAT target geneshave not been identified in these latter cell types.NFAT proteins appear to be regulated primarily at the level of theirsubcellular localisation . They are found exclusively in the cytoplasm ofresting T cells.nd consist of 2 components: a pre-existing cytoplasmiccomponent that translocates into the nucleus on calcium mobilisation.nd aninducible nuclear component comprising members of the activating protein-1(AP-1) family of transcription factors. In response to antigen receptorsignalling.he calcium-regulated phosphatase calcineurin acts directly todephosphorylate NFAT proteins.ausing their rapid translocation from thecytoplasm to the nucleus.here they cooperatively bind their target
  IPR008366:Nuclear factor of activated T cells (NFAT)
This domain is found in a number of transcription factors.ncluding p53.FATC.onEBP.TAT-1.nd NFkappaB.here it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis ; NFATC regulates the production of effector proteins involved in coordinating the immune response ; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth ; STAT-1 plays an important role in B lymphocyte growth and function ; and NFkappaB is involved in the inflammatory response . The DNA-binding domain acts to clamp.r in the case of TonEBP.ncircle the DNA target in order to stabilize the protein-DNA complex . Protein interactions may also serve to stabilize the protein-DNA complex.or example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability . The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors.ften within the DNA-binding domain.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008967:p53-like transcription factor, DNA-binding
The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors.hich includes NF-kappaB.orsal.elish.FAT.mong others. Some of these transcription factors appear to form multi-protein DNA-bound complexes . Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors.cting to modulate the expression of their target genes . The RHD is composed of two immunoglobulin-like beta-barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor.nd contains a recognition loop that interacts with DNA bases; the C-terminal dimerisation domain contains the site for interaction with I-kappaB .
  IPR011539:Rel homology
IPR011539:RHD 
Evalue:-50.9586067199707 
Location:410-570IPR002909:IPT 
Evalue:-17.8538719643218 
Location:577-676IPR000451:REL_1 
Evalue:0 
Location:0-0
SequencesProtein: NFAC2_HUMAN (925 aa)
mRNA: NM_012340 NM_173091
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK04446
  Level 3 annotation:
    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent
  Level 2 annotation:
    Wnt signaling pathway
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway
    B cell receptor signaling pathway
    Axon guidance
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 75 residues, 49441172-49441395Exon2: 232 residues, 49482010-49482700Exon3: 44 residues, 49485131-49485258Exon4: 20 residues, 49485649-49485705Exon5: 49 residues, 49504491-49504632Exon6: 59 residues, 49523923-49524096Exon7: 69 residues, 49525401-49525604Exon8: 59 residues, 49566729-49566901Exon9: 345 residues, 49573026-49574056Exon10: 118 residues, 49592315-49592665Exon11: 2 residues, -Jump to NFAC2_HUMANExon1: 75 residues, 49441172-49441395Exon2: 31 residues, 49448586-49448674Exon3: 232 residues, 49482010-49482700Exon4: 44 residues, 49485131-49485258Exon5: 20 residues, 49485649-49485705Exon6: 49 residues, 49504491-49504632Exon7: 59 residues, 49523923-49524096Exon8: 69 residues, 49525401-49525604Exon9: 59 residues, 49566729-49566901Exon10: 345 residues, 49573026-49574056Exon11: 118 residues, 49592315-49592665Exon12: 2 residues, -Jump to NFAC2_HUMAN  
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