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0NEUM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGAP43
DescriptionNeuromodulin (axonal membrane protein gap-43) (growth associated protein 43) (pp46) (neural phosphoprotein b-50).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0007205 protein kinase C activation (TAS)
0009611 response to wounding (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Neuromodulin is a component of the motile growth cones. It is membrane protein whose expression is widely correlated with successful axon elongation . It is a crucial component of an effective regeneration response in the nervous system . Although its function is uncertain.he N-terminal region is well conserved and contains both a calmodulin binding domain.nd sites for acylation.embrane attachment and protein kinase C phosphorylation. Structure predictions suggest that the C- terminus may exist as an extended.egatively-charged rod with some similarity to the side arms of neurofilaments.ndicating that the biological role of neuromodulin may depend on its ability to form a dynamic membrane-cytoplasm-calmodulin complex .
  IPR001422:Neuromodulin (GAP-43)
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
IPR001422:Neuromodulin 
Evalue:-102.638275146484 
Location:67-238IPR000048:IQ 
Evalue:-5.82390880584717 
Location:32-52IPR001422:NEUROMODULIN 
Evalue:0 
Location:2-16
SequencesProtein: NEUM_HUMAN (238 aa)
mRNA: NM_002045
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 116825141-116825256Exon2: 201 residues, 116877549-116878147Exon3: 172 residues, 116922330-116922842Exon4: 2 residues, -Jump to NEUM_HUMAN  
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