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0NEUG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNRGN
DescriptionNeurogranin (ng) (rc3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005516 calmodulin binding (TAS)
0007399 neurogenesis (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
IPR000048:IQ 
Evalue:-4.30980396270752 
Location:27-47
SequencesProtein: NEUG_HUMAN (78 aa)
mRNA: NM_006176
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 85 residues, 124114951-124115205Exon2: 77 residues, 124120608-124120835Exon3: 8 residues, 124121070-124121088Exon4: 268 residues, 124121509-124122307Exon5: 2 residues, -Jump to NEUG_HUMAN  
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Loci Cluster (Details)Loci: 2719 124240491-124256571 ~-16K 7985(ROBO3)(+)Loci: 2718 124114951-124122307 ~-7K 7977(NRGN)(+)Link out to UCSC