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0NETO2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionNeuropilin and tolloid-like protein 2 precursor (brain-specific transmembrane protein containing 2 cub and 1 ldl-receptor class a domains protein 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The CUB domain is an extracellular domain of approximately 110 residues which is found in functionally diverse.ostly developmentally regulated proteins .nd in peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin). Almost all CUB domains contain four conserved cysteines which probably form two disulphide bridges (C1-C2.3-C4). The structure of the CUB domain has been predicted to be a beta-barrel similar to that of immunoglobulins. Proteins that have been found to contain the CUB domain include mammalian complement subcomponents C1s/C1r.hich form the calcium-dependent complex C1.he first component of the classical pathway of the complement system; hamster serine protease Casp.hich degrades type I and IV collagen and fibronectin in the presence of calcium; mammalian complement-activating component of Ra-reactive factor (RARF). protease that cleaves the C4 component of complement; vertebrate enteropeptidase (). type II membrane protein of the intestinal brush border.hich activates trypsinogen; vertebrate bone morphogenic protein 1 (BMP-1). protein which induces cartilage and bone formation and expresses metalloendopeptidase activity; sea urchins blastula proteins BP10 and SpAN; Caenorhabditis elegans hypothetical proteins F42A10.8 and R151.5; neuropilin (A5 antigen). calcium-independent cell adhesion molecule that functions during the formation of certain neuronal circuits; fibropellins I and III from sea urchin; mammalian hyaluronate-binding protein TSG-6 (or PS4). serum and growth factor induced protein; mammalian spermadhesins; and Xenopus embryonic protein UVS.2.hich is expressed during dorsoanterior development.
Low density lipoprotein (LDL) is the major cholesterol-carrying lipoprotein of plasma. The receptor protein binds LDL and transports it into cells by endocytosis. In order to be internalised.he receptor-ligand complex must first cluster into clathrin-coated pits. Seven successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein .The LDL-receptor class A domain contains 6 disulphide-bound cysteines and a highly conserved cluster of negatively charged amino acids.f which many are clustered on one face of the module . A schematic representation of this domain is shown here:In LDL-receptors the class A domains form the binding site for LDL and calcium . The acidic residues between the fourth and sixth cysteines are important for high-affinity binding of positively charged sequences in LDLRs ligands . The repeat has been shown to consist of a beta-hairpin structure followed by a series of beta turns. In the absence of calcium.DL-A domains are unstructured; the bound calcium ion imparts structural integrity.Following these repeats is a 350 residue domain that resembles part of the epidermal growth factor (EGF) precursor .Similar domains have been found (see references in ) in several extracellular and membrane proteins (see examples).Numerous familial hypercholestorolemia mutations of the LDL receptor alter the calcium coordinating residue of LDL-A domains or other crucial scaffolding residues.
  IPR002172:Low density lipoprotein-receptor, class A
SequencesProtein: NETO2_HUMAN (525 aa)
mRNA: NM_018092
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 758 residues, 45672942-45675213Exon2: 40 residues, 45677637-45677751Exon3: 78 residues, 45700894-45701123Exon4: 44 residues, 45714068-45714196Exon5: 17 residues, 45714279-45714324Exon6: 85 residues, 45719736-45719985Exon7: 49 residues, 45720635-45720776Exon8: 21 residues, 45723380-45723437Exon9: 141 residues, 45734990-45735409Exon10: 2 residues, -Jump to NETO2_HUMAN  
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Loci Cluster (Details)Loci: 4222 45672942-45735409 ~-62K 14040(NETO2)(-)Loci: 4221 45251091-45280593 ~-30K 14029(VPS35)(-)Link out to UCSC