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0NED4L_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionE3 ubiquitin-protein ligase nedd-4-like protein (ec 6.3.2.-) (nedd4-2) (nedd4.2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (IC)
0005515 protein binding (IPI)
0017080 sodium channel regulator activity (IDA)
0004842 ubiquitin-protein ligase activity (NAS)
0007588 excretion (NAS)
0045807 positive regulation of endocytosis (NAS)
0016567 protein ubiquitination (NAS)
0042176 regulation of protein catabolism (NAS)
0010038 response to metal ion (IDA)
0006883 sodium ion homeostasis (NAS)
0006814 sodium ion transport (NAS)
0030104 water homeostasis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The name HECT comes from Homologous to the E6-AP Carboxyl Terminus . Proteins containing this domain at the C-terminus includeubiquitin-protein ligase.hich regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester.nd then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interactingprotein 12.hich also contains this domain.s a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediatedproteolysis.
The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes.ncluding phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies ofthe C1 domain in Protein Kinase C (that bind phorbol esters and diacylglycerol) (see )and the protein kinase catalytic domain (see ). Regions withsignificant homology to the C2-domain have been found in many proteins.The C2 domain is thought to be involved in calcium-dependent phospholipidbinding and in membrane targetting processes such as subcellular localisation. The 3D structure of theC2 domain of synaptotagmin has been reported.he domain forms an eight-stranded beta sandwich constructed around a conserved 4-stranded motif.esignated a C2 key . Calcium binds ina cup-shaped depression formed by the N- and C-terminal loops of theC2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel beta sandwich.
  IPR000008:C2 calcium-dependent membrane targeting
Synonym(s): Rsp5 or WWP domainThe WW domain is a short conserved region in a number ofunrelated proteins.hich folds as a stable.riple stranded beta-sheet.This short domain of approximately 40 amino acids.ay be repeated up to four times in some proteins . The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date.s well as that of aconserved Pro. The WW domain binds to proteins withparticular proline-motifs.AP]-P-P-[AP]-Y.nd/or phosphoserine- phosphothreonine-containing motifs . It is frequently associated with other domains typical for proteins insignal transduction processes.A large variety of proteins containing the WW domain are known. These include; dystrophin. multidomain cytoskeletal protein; utrophin. dystrophin-like protein of unknownfunction; vertebrate YAP protein.ubstrate of an unknown serine kinase; mouse NEDD-4.nvolved in the embryonic development and differentiation of the central nervous system;yeast RSP5.imilar to NEDD-4 in its molecular organization; rat FE65. transcription-factor activator expressed preferentially in liver; tobacco DB10 proteinand others.
Synonym(s): WWP domainThe WW domain. short conserved region found in a number of disparateproteins.s characterised by 2 conserved Trp residues and a conserved Pro(hence its alternative name.WP) . Among the proteins known to containWW domains is dystrophin.he product encoded by the gene responsible forDuchenne muscular dystrophy. The domain contains around 35-40 residues.nd may be repeated up to 4 times in some sequences. It appears to bindproteins that contain characteristic proline motifs ([AP]-P-P-[AP]-Y).nd resembles.o an extent.he SH3 domains. It is often associated withother domains that typify proteins involved in signal transduction.
The Ca2+-dependent.ipid-binding domain (CaLB) has been identified in a number of proteins.or example the amino-terminal.38 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008973:C2 calcium/lipid-binding region, CaLB
SequencesProtein: NED4L_HUMAN (975 aa)
mRNA: NM_015277
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentK03874
  Level 3 annotation:
    hect domain ubiquitin protein ligase E3 component
  Level 2 annotation:
    Ubiquitin mediated proteolysis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 53862777-53862938Exon2: 26 residues, 53984017-53984091Exon3: 29 residues, 54063638-54063720Exon4: 15 residues, 54067110-54067149Exon5: 20 residues, 54070212-54070266Exon6: 19 residues, 54134193-54134244Exon7: 22 residues, 54140636-54140698Exon8: 36 residues, 54141443-54141546Exon9: 57 residues, 54143207-54143374Exon10: 46 residues, 54147206-54147339Exon11: 61 residues, 54148949-54149126Exon12: 27 residues, 54152029-54152104Exon13: 46 residues, 54159249-54159381Exon14: 42 residues, 54159889-54160009Exon15: 68 residues, 54161117-54161315Exon16: 28 residues, 54167748-54167826Exon17: 20 residues, 54169202-54169257Exon18: 21 residues, 54175405-54175464Exon19: 24 residues, 54182479-54182545Exon20: 78 residues, 54184210-54184440Exon21: 42 residues, 54185957-54186079Exon22: 25 residues, 54188608-54188679Exon23: 34 residues, 54191385-54191481Exon24: 26 residues, 54201457-54201531Exon25: 22 residues, 54203737-54203798Exon26: 22 residues, 54205650-54205710Exon27: 38 residues, 54207296-54207404Exon28: 34 residues, 54208857-54208954Exon29: 26 residues, 54209698-54209771Exon30: 665 residues, 54214378-54216369Exon31: 2 residues, -Jump to NED4L_HUMAN  
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