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0NECP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNECAP2
DescriptionAdaptin ear-binding coat-associated protein 2 (necap-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030125 clathrin vesicle coat (ISS)
0005905 coated pit (ISS)
0005515 protein binding (ISS)
0006897 endocytosis (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
NECAP 1 localises to clathrin-coated pits and direct binding to the globular ear domain of the alpha-adaptin subunit (alpha-ear) of the adaptor protein 2 (AP-2) complex. This interaction is mediated by a specific motif.VQF.hat uses a distinct alpha-ear interface relative to known alpha-ear-binding partners. Disruption of this interaction blocks clathrin-mediated endocytosis .
  IPR012466:Adaptin ear-binding coat-associated protein 1 NECAP-1
IPR012466:DUF1681 
Evalue:-122.853874206543 
Location:4-192
SequencesProtein: NECP2_HUMAN (263 aa)
mRNA: NM_018090
Local Annotation
Synapse Ontology
all the components of the clathrin coat, major ones are clathrin and clathrin adaptors.
sdb:0261 clathrin coat component  (Evidence:keywords)
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 16639819-16639935Exon2: 35 residues, 16642713-16642814Exon3: 37 residues, 16646951-16647056Exon4: 29 residues, 16647141-16647223Exon5: 38 residues, 16648174-16648283Exon6: 61 residues, 16650919-16651097Exon7: 27 residues, 16654899-16654975Exon8: 414 residues, 16657923-16659159Exon9: 2 residues, -Jump to NECP2_HUMAN  
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