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0NECP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNECAP1
DescriptionAdaptin ear-binding coat-associated protein 1 (necap-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
NECAP 1 localises to clathrin-coated pits and direct binding to the globular ear domain of the alpha-adaptin subunit (alpha-ear) of the adaptor protein 2 (AP-2) complex. This interaction is mediated by a specific motif.VQF.hat uses a distinct alpha-ear interface relative to known alpha-ear-binding partners. Disruption of this interaction blocks clathrin-mediated endocytosis .
  IPR012466:Adaptin ear-binding coat-associated protein 1 NECAP-1
IPR012466:DUF1681 
Evalue:-126.522880554199 
Location:5-191
SequencesProtein: NECP1_HUMAN (275 aa)
mRNA: NM_015509
Local Annotation
Synapse Ontology
all the components of the clathrin coat, major ones are clathrin and clathrin adaptors.
sdb:0261 clathrin coat component  (Evidence:keywords)
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 33 residues, 8126150-8126246Exon2: 35 residues, 8133798-8133899Exon3: 37 residues, 8134057-8134162Exon4: 29 residues, 8135631-8135713Exon5: 38 residues, 8136538-8136647Exon6: 63 residues, 8136734-8136918Exon7: 36 residues, 8139463-8139566Exon8: 578 residues, 8139904-8141634Exon9: 2 residues, -Jump to NECP1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4014 8177634-8178714 ~-1K 8324(-)Loci: 2735 8126150-8141634 ~-15K 8320(NECAP1)(+)Link out to UCSC