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0NECD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNDN
DescriptionNecdin.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008285 negative regulation of cell proliferation (TAS)
0007399 neurogenesis (TAS)
0000074 regulation of progression through cell cycle (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The first mammalian members of the MAGE (melanoma-associated antigen) genefamily were originally described as completely silent in normal adult tissues.ith the exception of male germ cells and.or some of them.lacenta. Bycontrast.hese genes were expressed in various kinds of tumors. However.thermembers of the family were recently found to be expressed in normal cells.ndicating that the family is larger and more disparate than initiallyexpected. MAGE-like genes have also been identified in non-mammalian species.ike the zebrafish or Drosophila melanogaster. Although no MAGE homologoussequences have been identified in Caenorhabditis elegans.accharomycescerevisiae or Schizosaccharomyces pombe.AGE sequences have been found inseveral vegetal species.ncluding Arabidopsis thaliana .The only region of homology shared by all of the members of the family is astretch of about 200 amino acids which has been named the MAGE conserveddomain. The MAGE conserved domain is usually located close to the C-terminal.lthough it can also be found in a more central position in some proteins. TheMAGE conserved domain is generally present as a single copy but it isduplicated in some proteins. It has been proposed that the MAGE conserveddomain of MAGE-D proteins might interact with p75 neurotrophin or relatedreceptors .
  IPR002190:MAGE protein
IPR002190:MAGE 
Evalue:-72.9208221435547 
Location:1-220
SequencesProtein: NECD_HUMAN (321 aa)
mRNA: NM_002487
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 630 residues, 21481654-21483543Exon2: 2 residues, -Jump to NECD_HUMAN  
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