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0NDKM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNME4
DescriptionNucleoside diphosphate kinase, mitochondrial precursor (ec 2.7.4.6) (ndp kinase, mitochondrial) (ndk) (nm23-h4) (nucleoside diphosphate kinase d) (ndpkd).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004550 nucleoside diphosphate kinase activity (TAS)
0009116 nucleoside metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Nucleoside diphosphate kinases () (NDK) are enzymes required for the synthesis of nucleoside triphosphates (NTP) other than ATP. They provide NTPs for nucleic acid synthesis.TP for lipid synthesis.TP for polysaccharide synthesis and GTP for protein elongation.ignal transduction and microtubule polymerization.In eukaryotes.here seems to be a small family of NDK isozymes each of which acts in a different subcellular compartment and/or has a distinct biological function. Eukaryotic NDK isozymes are hexamers of two highly related chains (A and B) . By random association (A6.5B...AB5.6).hese two kinds of chain form isoenzymes differing in their isoelectric point.NDK are proteins of 17 Kd that act via a ping-pong mechanism in which a histidine residue is phosphorylated.y transfer of the terminal phosphate group from ATP. In the presence of magnesium.he phosphoenzyme can transfer its phosphate group to any NDP.o produce an NTP.NDK isozymes have been sequenced from prokaryotic and eukaryotic sources. It has also been shown that the Drosophila awd (abnormal wing discs) protein.s a microtubule-associated NDK. Mammalian NDK is also known as metastasis inhibition factor nm23. The sequence of NDK has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes.hich is involved in the catalytic mechanism . Our signature pattern contains this residue.
  IPR001564:Nucleoside diphosphate kinase
IPR001564:NDK 
Evalue:-82.6197887582884 
Location:37-174
SequencesProtein: NDKM_HUMAN (187 aa)
mRNA: NM_005009
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00940
  Level 3 annotation:
    nucleoside-diphosphate kinase
  Level 2 annotation:
    Purine metabolism
    Pyrimidine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 387192-387314Exon2: 46 residues, 388990-389124Exon3: 36 residues, 389379-389481Exon4: 39 residues, 389627-389740Exon5: 180 residues, 390219-390754Exon6: 2 residues, -Jump to NDKM_HUMAN  
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Loci Cluster (Details)Loci: 2909 387192-390754 ~-4K 13162(NME4)(+)Loci: 2910 415668-512481 ~-97K 13166(RAB11FIP3)(+)Loci: 2911 580179-619272 ~-39K 13173(RAB40C)(+)Loci: 4199 774975-778384 ~-3K 13216(-)Loci: 2912 1143241-1211772 ~-69K 13223(CACNA1H)(+)Loci: 2913 1324663-1339443 ~-15K 13234(BAIAP3)(+)Loci: 4200 1435345-1465013 ~-30K 13244(CLCN7)(-)Loci: 2914 1696221-1760318 ~-64K 13253(MAPK8IP3)(+)Loci: 2915 1979968-1984276 ~-4K 13288(SYNGR3)(+)Loci: 2916 2016896-2028484 ~-12K 13290(SLC9A3R2)(+)Loci: 2917 2038599-2078713 ~-40K 13294(TSC2)(+)Loci: 2918 2138651-2144141 ~-5K 13300(RAB26)(+)Loci: 4201 2167184-2186466 ~-19K 13303(CASKIN1)(-)Loci: 4198 357394-360541 ~-3K 13159(MRPL28)(-)Link out to UCSC