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0NCTR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNCR1
DescriptionNatural cytotoxicity triggering receptor 1 precursor (natural killer cell p46-related protein) (nkp46) (hnkp46) (nk-p46) (nk cell activating receptor) (lymphocyte antigen 94 homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (NAS)
0016514 SWI/SNF complex (ISS)
0005515 protein binding (ISS)
0005057 receptor signaling protein activity (TAS)
0006968 cellular defense response (TAS)
0030101 natural killer cell activation (NAS)
0042269 regulation of natural killer cell mediated ... (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda.ach composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha.elta.psilon.amma and mu.ll consisting of a variable domain (VH) and three (in alpha.elta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins.n which the variable and constant domains have clear.onserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ).1-set (constant-1; ).2-set (constant-2; ) and I-set (intermediate; ) . Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure.ith the types differing in the number of strands in the beta-sheets as well as in their sequence patterns .Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions.ncluding cell-cell recognition.ell-surface receptors.uscle structure and the immune system . This subfamily includes:Cell surface receptors containing an immunoglobin domain.Killer cell inhibitory receptors.Oprin a snake venom metalloproteinase inhibitor from Didelphis marsupialis (Southern opossum) .hich belongs to MEROPS inhibitor family I43.lan I- .Oprin homologues.
  IPR003599:Immunoglobulin subtype
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
IPR003599:IG 
Evalue:-2.74472749489669 
Location:129-211IPR013783:Ig-like_fold 
Evalue:0 
Location:27-118IPR007110:IG_LIKE 
Evalue:0 
Location:0-0
SequencesProtein: NCTR1_HUMAN (304 aa)
mRNA: BC064806 NM_004829
Local Annotation
Synapse Ontology
A typical resting membrane potential for neurons varies from -65 to -90 mV. This potential represents the sum of the equilibrium potentials for each contributing ion.
sdb:0237 resting membrane potentiaion  (Evidence:keywords)
KO assignmentK06741
  Level 3 annotation:
    natural cytotoxicity triggering receptor 1
  Level 2 annotation:
    CD molecules
    Natural killer cell mediated cytotoxicity
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 25 residues, 60109319-60109391Exon2: 14 residues, 60109468-60109504Exon3: 97 residues, 60109692-60109977Exon4: 95 residues, 60112415-60112694Exon5: 18 residues, 60113189-60113237Exon6: 19 residues, 60115347-60115398Exon7: 130 residues, 60115869-60116253Exon8: 69 residues, 60118993-60119194Exon9: 2 residues, -Jump to NCTR1_HUMANExon1: 20 residues, 60109332-60109391Exon2: 14 residues, 60109468-60109504Exon3: 97 residues, 60109692-60109977Exon4: 95 residues, 60112415-60112694Exon5: 18 residues, 60113189-60113237Exon6: 18 residues, 60115350-60115398Exon7: 157 residues, 60115869-60116336Exon8: 101 residues, 60119021-60119319Exon9: 2 residues, -Jump to NCTR1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4417 60376280-60382727 ~-6K 19696(SYT5)(-)Loci: 4418 60558092-60566432 ~-8K 19713(C19orf16)(-)Loci: 3140 60878403-60898944 ~-21K 19736(EPN1)(+)Loci: 3139 60109319-60119319 ~-10K 19661(NCR1)(+)Link out to UCSC