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0MYRIP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionRab effector myrip (myosin-viia- and rab-interacting protein) (exophilin-8) (slp homolog lacking c2 domains-c).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
MOBP is abundantly expressed in central nervous system myelin.nd shares several characteristics with myelin basic protein (MBP).n terms of regional distribution and function. MOBP has been shown to be essential for normal arrangement of the radial component in central nervous system myelin .
  IPR006788:Myelin-associated oligodendrocytic basic protein (MOBP)
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
SequencesProtein: MYRIP_HUMAN (859 aa)
mRNA: NM_015460
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 36 residues, 39826306-39826411Exon2: 48 residues, 39917281-39917421Exon3: 76 residues, 40060544-40060766Exon4: 47 residues, 40167542-40167679Exon5: 29 residues, 40179224-40179305Exon6: 34 residues, 40183340-40183438Exon7: 29 residues, 40183653-40183734Exon8: 50 residues, 40186444-40186588Exon9: 53 residues, 40198714-40198868Exon10: 214 residues, 40206320-40206958Exon11: 82 residues, 40226348-40226588Exon12: 67 residues, 40250353-40250548Exon13: 56 residues, 40260940-40261102Exon14: 37 residues, 40266716-40266821Exon15: 22 residues, 40266933-40266994Exon16: 41 residues, 40268375-40268494Exon17: 728 residues, 40274628-40276808Exon18: 2 residues, -Jump to MYRIP_HUMAN  
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