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0MYPT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPP1R12A
DescriptionProtein phosphatase 1 regulatory subunit 12a (myosin phosphatase targeting subunit 1) (myosin phosphatase target subunit 1) (protein phosphatase myosin-binding subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004871 signal transducer activity (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
  IPR002110:Ankyrin
IPR002110:Ank 
Evalue:-9.82390880584717 
Location:72-104IPR002110:Ank 
Evalue:-8.74472713470459 
Location:198-230IPR002110:Ank 
Evalue:-8.30103015899658 
Location:105-137IPR002110:Ank 
Evalue:-6.36653137207031 
Location:231-263IPR002110:Ank 
Evalue:-1.12493872642517 
Location:47-71IPR002110:Ank 
Evalue:0.672097861766815 
Location:138-171
SequencesProtein: MYPT1_HUMAN (1030 aa)
mRNA: NM_002480
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK06270
  Level 3 annotation:
    protein phosphatase 1, regulatory (inhibitor) subunit 12
  Level 2 annotation:
    Regulation of actin cytoskeleton
    Focal adhesion
    Long-term potentiation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 537 residues, 78692316-78693926Exon2: 19 residues, 78696460-78696511Exon3: 18 residues, 78699725-78699773Exon4: 37 residues, 78704284-78704389Exon5: 47 residues, 78706558-78706694Exon6: 7 residues, 78708377-78708394Exon7: 24 residues, 78711773-78711839Exon8: 42 residues, 78713548-78713670Exon9: 58 residues, 78714692-78714861Exon10: 69 residues, 78715105-78715306Exon11: 32 residues, 78716404-78716495Exon12: 61 residues, 78723502-78723679Exon13: 58 residues, 78724076-78724244Exon14: 37 residues, 78725136-78725241Exon15: 33 residues, 78726393-78726488Exon16: 74 residues, 78727705-78727921Exon17: 43 residues, 78735304-78735429Exon18: 54 residues, 78738684-78738842Exon19: 31 residues, 78738988-78739077Exon20: 27 residues, 78740026-78740101Exon21: 50 residues, 78746230-78746375Exon22: 55 residues, 78750242-78750402Exon23: 41 residues, 78763212-78763331Exon24: 45 residues, 78790718-78790849Exon25: 81 residues, 78852605-78852842Exon26: 2 residues, -Jump to MYPT1_HUMAN  
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Loci Cluster (Details)Loci: 4062 78509877-78608921 ~-99K 9374(PAWR)(-)Loci: 4063 78692316-78852842 ~-161K 9375(PPP1R12A)(-)Loci: 2775 78135413-78368971 ~-234K 9373(SYT1)(+)Link out to UCSC