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0MYO5B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionMyosin-5b (myosin vb).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .The globular head is well conserved.ome highly-conserved regions possibly relating to functional and structural domains . The rod-like tail starts with an invariant proline residue.nd contains many repeats of a 28 residue region.nterrupted at 4 regularly-spaced points known as skip residues. Although the sequence of the tail is not well conserved.he chemical character is.ydrophobic.harged and skip residues occuring in a highly ordered and repeated fashion .
  IPR001609:Myosin head, motor region
Dilute encodes a novel type of myosin heavy chain.ith a tail.r C-terminal.egion that has elements of both type II (alpha-helical coiled-coil) and type I (non-coiled-coil) myosin heavy chains. The DIL non alpha-helical domain is found in dilute myosin heavy chain proteins and other myosins. In mouse the dilute protein may play a role in the elaboration.aintenance.r function of cellular processes of melanocytes and neurons .The MYO2 protein of Saccharomyces cerevisiae is implicated in vectorial vesicle transport and is homologous to the dilute protein over practically its entire length .
Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain.ontaining the ATP- and actin-binding sites.nd the lever arm.hich amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain.he upper 50-kDa subdomain.he lower 50-kDa subdomain.nd the C-terminal converter subdomain . The N-terminal subdomain has an SH3-like partly opened beta barrel topology.ith the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008989:Myosin S1 fragment, N-terminal
SequencesProtein: MYO5B_HUMAN (1849 aa)
mRNA: No corresponding mRNA found
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01580
  Level 3 annotation:
    glutamate decarboxylase
  Level 2 annotation:
    Butanoate metabolism
    Glutamate metabolism
    Alanine and aspartate metabolism
    beta-Alanine metabolism
    Taurine and hypotaurine metabolism
    Type I diabetes mellitus
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1270 residues, 45603183-45606991Exon2: 29 residues, 45615711-45615792Exon3: 60 residues, 45617078-45617253Exon4: 97 residues, 45617884-45618170Exon5: 52 residues, 45619511-45619662Exon6: 32 residues, 45621732-45621822Exon7: 52 residues, 45623608-45623760Exon8: 50 residues, 45627513-45627657Exon9: 33 residues, 45629934-45630028Exon10: 68 residues, 45633816-45634015Exon11: 28 residues, 45637180-45637258Exon12: 35 residues, 45643594-45643695Exon13: 82 residues, 45644508-45644748Exon14: 24 residues, 45652534-45652600Exon15: 49 residues, 45656054-45656195Exon16: 42 residues, 45658130-45658250Exon17: 50 residues, 45659312-45659458Exon18: 30 residues, 45660738-45660823Exon19: 80 residues, 45675308-45675542Exon20: 82 residues, 45682961-45683201Exon21: 54 residues, 45685039-45685196Exon22: 72 residues, 45686786-45686998Exon23: 39 residues, 45692429-45692541Exon24: 31 residues, 45709879-45709966Exon25: 34 residues, 45716619-45716717Exon26: 53 residues, 45717612-45717765Exon27: 30 residues, 45733627-45733711Exon28: 43 residues, 45734680-45734803Exon29: 49 residues, 45742633-45742774Exon30: 29 residues, 45743316-45743398Exon31: 90 residues, 45754717-45754983Exon32: 38 residues, 45760811-45760921Exon33: 38 residues, 45765085-45765193Exon34: 29 residues, 45770806-45770888Exon35: 50 residues, 45772655-45772799Exon36: 54 residues, 45781622-45781779Exon37: 50 residues, 45817217-45817362Exon38: 59 residues, 45820510-45820682Exon39: 39 residues, 45835635-45835746Exon40: 16 residues, 45975134-45975176Exon41: 2 residues, -Jump to MYO5B_HUMAN  
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Loci Cluster (Details)Loci: 4341 45603183-45975176 ~-372K 17298(MYO5B)(-)Loci: 4340 45563872-45593900 ~-30K 17296(ACAA2)(-)Link out to UCSC