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0MYO1C_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMYO1C
DescriptionMyosin ic (myosin i beta) (mmi-beta) (mmib).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016461 unconventional myosin (TAS)
0009592 detection of sound (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
These proteins share a region of sequence similarity with the tail of myosin (for example ).Myosins act as molecular motors.
  IPR010926:Myosin tail 2
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .The globular head is well conserved.ome highly-conserved regions possibly relating to functional and structural domains . The rod-like tail starts with an invariant proline residue.nd contains many repeats of a 28 residue region.nterrupted at 4 regularly-spaced points known as skip residues. Although the sequence of the tail is not well conserved.he chemical character is.ydrophobic.harged and skip residues occuring in a highly ordered and repeated fashion .
  IPR001609:Myosin head, motor region
IPR001609:MYSc 
Evalue:-1e+125 
Location:5-697IPR010926:Myosin_TH1 
Evalue:-77.7695541381836 
Location:838-1024IPR000048:IQ 
Evalue:-3.67778070526608 
Location:721-743IPR000048:IQ 
Evalue:-3.42021632194519 
Location:700-720
SequencesProtein: MYO1C_HUMAN (1028 aa)
mRNA: NM_033375
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 308 residues, 1314874-1315796Exon2: 35 residues, 1317285-1317385Exon3: 34 residues, 1317523-1317621Exon4: 25 residues, 1317883-1317954Exon5: 47 residues, 1318031-1318167Exon6: 20 residues, 1318296-1318352Exon7: 33 residues, 1318446-1318540Exon8: 30 residues, 1319574-1319658Exon9: 55 residues, 1320218-1320378Exon10: 30 residues, 1320478-1320563Exon11: 25 residues, 1320664-1320733Exon12: 27 residues, 1321114-1321191Exon13: 40 residues, 1321266-1321380Exon14: 41 residues, 1321950-1322068Exon15: 37 residues, 1322166-1322272Exon16: 29 residues, 1324653-1324734Exon17: 17 residues, 1324855-1324902Exon18: 33 residues, 1324981-1325076Exon19: 32 residues, 1327548-1327640Exon20: 29 residues, 1327934-1328015Exon21: 37 residues, 1328130-1328236Exon22: 29 residues, 1328453-1328536Exon23: 42 residues, 1328659-1328779Exon24: 26 residues, 1329474-1329546Exon25: 40 residues, 1329635-1329749Exon26: 35 residues, 1330570-1330669Exon27: 62 residues, 1330749-1330929Exon28: 29 residues, 1332521-1332602Exon29: 68 residues, 1332904-1333103Exon30: 40 residues, 1333653-1333769Exon31: 54 residues, 1334191-1334347Exon32: 98 residues, 1342456-1342745Exon33: 2 residues, -Jump to MYO1C_HUMAN  
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Loci Cluster (Details)Loci: 4246 1314874-1342745 ~-28K 14799(MYO1C)(-)Loci: 4247 1483902-1495791 ~-12K 14809(SCARF1)(-)Loci: 2965 1612008-1627617 ~-16K 14821(SERPINF1)(+)Loci: 4245 1194594-1250267 ~-56K 14796(YWHAE)(-)Link out to UCSC