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0MYH7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMYH7
DescriptionMyosin heavy chain, cardiac muscle beta isoform (myhc-beta).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005859 muscle myosin (TAS)
0005524 ATP binding (NAS)
0000146 microfilament motor activity (NAS)
0008307 structural constituent of muscle (TAS)
0006936 muscle contraction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .This family consists of the coiled-coil myosin heavy chain tail region.The coiled-coil is composed of the tail from two molecules of myosin.These can then assemble into the macromolecular thick filament .The coiled-coil region provides the structural backbone of the thick filament .
  IPR002928:Myosin tail
This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
  IPR004009:Myosin, N-terminal, SH3-like
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .The globular head is well conserved.ome highly-conserved regions possibly relating to functional and structural domains . The rod-like tail starts with an invariant proline residue.nd contains many repeats of a 28 residue region.nterrupted at 4 regularly-spaced points known as skip residues. Although the sequence of the tail is not well conserved.he chemical character is.ydrophobic.harged and skip residues occuring in a highly ordered and repeated fashion .
  IPR001609:Myosin head, motor region
IPR002928:Myosin_tail_1 
Evalue:-1e+125 
Location:1068-1926IPR001609:MYSc 
Evalue:-1e+125 
Location:79-779IPR004009:Myosin_N 
Evalue:-17.5850257873535 
Location:34-75IPR000048:IQ 
Evalue:-3.03621220588684 
Location:782-802
SequencesProtein: MYH7_HUMAN (1935 aa)
mRNA: NM_000257
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 44 residues, 22951789-22951920Exon2: 47 residues, 22952807-22952942Exon3: 34 residues, 22953055-22953151Exon4: 94 residues, 22954043-22954319Exon5: 44 residues, 22954429-22954555Exon6: 70 residues, 22954677-22954881Exon7: 105 residues, 22955052-22955361Exon8: 43 residues, 22955916-22956041Exon9: 57 residues, 22956201-22956367Exon10: 63 residues, 22956551-22956735Exon11: 67 residues, 22957258-22957455Exon12: 41 residues, 22958225-22958344Exon13: 44 residues, 22958531-22958658Exon14: 132 residues, 22958893-22959283Exon15: 32 residues, 22960006-22960097Exon16: 50 residues, 22961228-22961374Exon17: 61 residues, 22962595-22962772Exon18: 83 residues, 22962955-22963198Exon19: 87 residues, 22963817-22964073Exon20: 47 residues, 22964330-22964467Exon21: 43 residues, 22964743-22964867Exon22: 41 residues, 22965012-22965130Exon23: 31 residues, 22965825-22965913Exon24: 24 residues, 22966288-22966356Exon25: 105 residues, 22966633-22966943Exon26: 59 residues, 22967548-22967719Exon27: 52 residues, 22968003-22968153Exon28: 41 residues, 22968277-22968396Exon29: 48 residues, 22968823-22968962Exon30: 36 residues, 22969608-22969712Exon31: 35 residues, 22969949-22970048Exon32: 23 residues, 22970466-22970530Exon33: 33 residues, 22970633-22970726Exon34: 38 residues, 22970809-22970918Exon35: 11 residues, 22971527-22971555Exon36: 54 residues, 22971687-22971844Exon37: 50 residues, 22972132-22972276Exon38: 71 residues, 22972580-22972789Exon39: 25 residues, 22973242-22973312Exon40: 2 residues, -Jump to MYH7_HUMAN  
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Loci Cluster (Details)Loci: 4116 22525950-22549192 ~-23K 10843(C14orf93)(-)Loci: 4117 22597615-22634663 ~-37K 10853(ACIN1)(-)Loci: 2824 22845875-22850798 ~-5K 10860(BCL2L2)(+)Loci: 2825 22859236-22865202 ~-6K 10861(PABPN1)(+)Loci: 4118 22895451-22904682 ~-9K 10864(EFS)(-)Loci: 4119 22921038-22947324 ~-26K 10871(MYH6)(-)Loci: 4120 22951789-22973312 ~-22K 10872(MYH7)(-)Loci: 4121 23059904-23065839 ~-6K 10876(ZFHX2)(-)Loci: 4122 23098616-23107119 ~-9K 10881(AP1G2)(-)Loci: 4115 22439745-22458214 ~-18K 10832(RBM23)(-)Link out to UCSC