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0MYH6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMYH6
DescriptionMyosin heavy chain, cardiac muscle alpha isoform (myhc-alpha).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005859 muscle myosin (TAS)
0003779 actin binding (NAS)
0005524 ATP binding (NAS)
0005516 calmodulin binding (NAS)
0000146 microfilament motor activity (NAS)
0006936 muscle contraction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .This family consists of the coiled-coil myosin heavy chain tail region.The coiled-coil is composed of the tail from two molecules of myosin.These can then assemble into the macromolecular thick filament .The coiled-coil region provides the structural backbone of the thick filament .
  IPR002928:Myosin tail
This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
  IPR004009:Myosin, N-terminal, SH3-like
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
Tropomyosins .re a family of closely related proteins present in muscle and non-muscle cells. In striated muscle.ropomyosin mediate the interactions between the troponin complex and actin so as to regulate muscle contraction . The role of tropomyosin in smooth muscle and non-muscle tissues is not clear. Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites . There are multiple cell-specific isoforms.reated by differential splicing of the messenger RNA from one gene.ut the proportions of the isoforms vary between different cell types. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region.hereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen.tings.rugs.r food) that.n most people.esult in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P..offmann D..oewenstein H..arsh D.G..latts-Mills T.A.E..homas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations.hey are discriminated from one anotherby adding one or more letters (as necessary) to each species designation. The allergens in this family include allergens with the following designations: Met e 1.
  IPR000533:Tropomyosin
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .The globular head is well conserved.ome highly-conserved regions possibly relating to functional and structural domains . The rod-like tail starts with an invariant proline residue.nd contains many repeats of a 28 residue region.nterrupted at 4 regularly-spaced points known as skip residues. Although the sequence of the tail is not well conserved.he chemical character is.ydrophobic.harged and skip residues occuring in a highly ordered and repeated fashion .
  IPR001609:Myosin head, motor region
IPR002928:Myosin_tail_1 
Evalue:-1e+125 
Location:1070-1928IPR001609:MYSc 
Evalue:-1e+125 
Location:79-781IPR004009:Myosin_N 
Evalue:-17.8538722991943 
Location:34-75IPR000048:IQ 
Evalue:-1.14266753196716 
Location:784-804IPR000533:TROPOMYOSIN 
Evalue:0 
Location:0-0IPR000048:IQ 
Evalue:2.51851393987789 
Location:808-830
SequencesProtein: MYH6_HUMAN (1939 aa)
mRNA: NM_002471
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 25 residues, 22921038-22921112Exon2: 47 residues, 22921476-22921611Exon3: 34 residues, 22922273-22922369Exon4: 94 residues, 22923490-22923766Exon5: 44 residues, 22923964-22924090Exon6: 70 residues, 22924976-22925180Exon7: 105 residues, 22925363-22925672Exon8: 43 residues, 22926577-22926702Exon9: 57 residues, 22926806-22926972Exon10: 63 residues, 22927203-22927387Exon11: 67 residues, 22927907-22928104Exon12: 41 residues, 22928441-22928560Exon13: 44 residues, 22928641-22928768Exon14: 132 residues, 22929105-22929495Exon15: 32 residues, 22931610-22931701Exon16: 50 residues, 22931960-22932106Exon17: 61 residues, 22932390-22932567Exon18: 83 residues, 22932714-22932957Exon19: 87 residues, 22933116-22933372Exon20: 47 residues, 22935332-22935469Exon21: 43 residues, 22935742-22935866Exon22: 41 residues, 22936011-22936129Exon23: 31 residues, 22936218-22936306Exon24: 25 residues, 22936591-22936662Exon25: 105 residues, 22937776-22938086Exon26: 59 residues, 22939304-22939475Exon27: 91 residues, 22939757-22940026Exon28: 48 residues, 22941512-22941651Exon29: 36 residues, 22941745-22941849Exon30: 35 residues, 22942396-22942495Exon31: 23 residues, 22942763-22942827Exon32: 33 residues, 22943344-22943437Exon33: 39 residues, 22943759-22943871Exon34: 11 residues, 22944148-22944176Exon35: 54 residues, 22944271-22944428Exon36: 50 residues, 22944675-22944819Exon37: 73 residues, 22946071-22946285Exon38: 13 residues, 22946624-22946657Exon39: 9 residues, 22947301-22947324Exon40: 2 residues, -Jump to MYH6_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4116 22525950-22549192 ~-23K 10843(C14orf93)(-)Loci: 4117 22597615-22634663 ~-37K 10853(ACIN1)(-)Loci: 2824 22845875-22850798 ~-5K 10860(BCL2L2)(+)Loci: 2825 22859236-22865202 ~-6K 10861(PABPN1)(+)Loci: 4118 22895451-22904682 ~-9K 10864(EFS)(-)Loci: 4119 22921038-22947324 ~-26K 10871(MYH6)(-)Loci: 4120 22951789-22973312 ~-22K 10872(MYH7)(-)Loci: 4121 23059904-23065839 ~-6K 10876(ZFHX2)(-)Loci: 4122 23098616-23107119 ~-9K 10881(AP1G2)(-)Loci: 4115 22439745-22458214 ~-18K 10832(RBM23)(-)Link out to UCSC