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0MYH3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMYH3
DescriptionMyosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000146 microfilament motor activity (NAS)
0030048 actin filament-based movement (NAS)
0007517 muscle development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .This family consists of the coiled-coil myosin heavy chain tail region.The coiled-coil is composed of the tail from two molecules of myosin.These can then assemble into the macromolecular thick filament .The coiled-coil region provides the structural backbone of the thick filament .
  IPR002928:Myosin tail
This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
  IPR004009:Myosin, N-terminal, SH3-like
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .The globular head is well conserved.ome highly-conserved regions possibly relating to functional and structural domains . The rod-like tail starts with an invariant proline residue.nd contains many repeats of a 28 residue region.nterrupted at 4 regularly-spaced points known as skip residues. Although the sequence of the tail is not well conserved.he chemical character is.ydrophobic.harged and skip residues occuring in a highly ordered and repeated fashion .
  IPR001609:Myosin head, motor region
IPR002928:Myosin_tail_1 
Evalue:-1e+125 
Location:1069-1927IPR001609:MYSc 
Evalue:-1e+125 
Location:80-780IPR004009:Myosin_N 
Evalue:-16.6777801513672 
Location:35-76IPR000048:IQ 
Evalue:-2.02687215805054 
Location:783-803
SequencesProtein: MYH3_HUMAN (1940 aa)
mRNA: NM_002470
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 49 residues, 10472575-10472721Exon2: 48 residues, 10473638-10473776Exon3: 34 residues, 10473883-10473979Exon4: 37 residues, 10474133-10474238Exon5: 59 residues, 10474329-10474500Exon6: 44 residues, 10475652-10475778Exon7: 70 residues, 10475854-10476058Exon8: 105 residues, 10476517-10476826Exon9: 43 residues, 10477632-10477757Exon10: 57 residues, 10478058-10478224Exon11: 63 residues, 10478881-10479065Exon12: 67 residues, 10479408-10479605Exon13: 41 residues, 10479776-10479895Exon14: 44 residues, 10481850-10481977Exon15: 132 residues, 10482084-10482474Exon16: 32 residues, 10482914-10483005Exon17: 50 residues, 10483085-10483231Exon18: 61 residues, 10483339-10483516Exon19: 83 residues, 10483601-10483844Exon20: 87 residues, 10484037-10484293Exon21: 47 residues, 10484374-10484511Exon22: 43 residues, 10484604-10484728Exon23: 41 residues, 10485126-10485244Exon24: 31 residues, 10485326-10485414Exon25: 25 residues, 10486281-10486352Exon26: 104 residues, 10486458-10486765Exon27: 59 residues, 10486867-10487038Exon28: 52 residues, 10488392-10488542Exon29: 41 residues, 10488625-10488744Exon30: 48 residues, 10489748-10489887Exon31: 36 residues, 10489970-10490074Exon32: 35 residues, 10491223-10491322Exon33: 23 residues, 10491404-10491468Exon34: 33 residues, 10492598-10492691Exon35: 38 residues, 10493618-10493726Exon36: 11 residues, 10494414-10494443Exon37: 54 residues, 10495553-10495710Exon38: 50 residues, 10496461-10496605Exon39: 72 residues, 10498902-10499114Exon40: 22 residues, 10500131-10500192Exon41: 2 residues, -Jump to MYH3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4266 10472575-10500192 ~-28K 15163(MYH3)(-)Loci: 4267 10524379-10541562 ~-17K 15164(SCO1)(-)Loci: 4265 10144907-10217047 ~-72K 15157(MYH13)(-)Link out to UCSC