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0MYH13_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMYH13
DescriptionMyosin-13 (myosin heavy chain, skeletal muscle, extraocular) (myhc- eo).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005859 muscle myosin (TAS)
0003779 actin binding (NAS)
0005524 ATP binding (NAS)
0005516 calmodulin binding (NAS)
0000146 microfilament motor activity (TAS)
0006936 muscle contraction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .This family consists of the coiled-coil myosin heavy chain tail region.The coiled-coil is composed of the tail from two molecules of myosin.These can then assemble into the macromolecular thick filament .The coiled-coil region provides the structural backbone of the thick filament .
  IPR002928:Myosin tail
This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
  IPR004009:Myosin, N-terminal, SH3-like
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains . alkali light chains.nd 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail.lthough some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains.oded for by a multi-gene family . Myosin interacts with actin to convert chemical energy.n the form of ATP.o mechanical energy . The 3-D structure of the head portion of myosin has been determined and a model for actin-myosin complex has been constructed .The globular head is well conserved.ome highly-conserved regions possibly relating to functional and structural domains . The rod-like tail starts with an invariant proline residue.nd contains many repeats of a 28 residue region.nterrupted at 4 regularly-spaced points known as skip residues. Although the sequence of the tail is not well conserved.he chemical character is.ydrophobic.harged and skip residues occuring in a highly ordered and repeated fashion .
  IPR001609:Myosin head, motor region
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
IPR002928:Myosin_tail_1 
Evalue:-1e+125 
Location:1072-1930IPR001609:MYSc 
Evalue:-1e+125 
Location:80-783IPR004009:Myosin_N 
Evalue:-16.2924289703369 
Location:35-76IPR000048:IQ 
Evalue:0 
Location:785-814
SequencesProtein: MYH13_HUMAN (1938 aa)
mRNA: NM_003802
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 10144907-10145007Exon2: 47 residues, 10145610-10145745Exon3: 34 residues, 10147237-10147333Exon4: 37 residues, 10147435-10147540Exon5: 59 residues, 10150500-10150671Exon6: 44 residues, 10150980-10151106Exon7: 70 residues, 10153275-10153479Exon8: 105 residues, 10153563-10153872Exon9: 43 residues, 10155144-10155269Exon10: 57 residues, 10155952-10156118Exon11: 63 residues, 10156615-10156799Exon12: 67 residues, 10157199-10157396Exon13: 41 residues, 10159734-10159853Exon14: 44 residues, 10159940-10160067Exon15: 132 residues, 10162831-10163221Exon16: 32 residues, 10164194-10164285Exon17: 50 residues, 10164392-10164538Exon18: 61 residues, 10165573-10165750Exon19: 83 residues, 10168063-10168306Exon20: 87 residues, 10171907-10172163Exon21: 47 residues, 10174428-10174565Exon22: 43 residues, 10176140-10176264Exon23: 41 residues, 10177115-10177233Exon24: 31 residues, 10184191-10184279Exon25: 26 residues, 10184369-10184441Exon26: 106 residues, 10187839-10188151Exon27: 59 residues, 10189243-10189414Exon28: 52 residues, 10189508-10189658Exon29: 41 residues, 10190721-10190840Exon30: 48 residues, 10194597-10194736Exon31: 36 residues, 10198721-10198825Exon32: 35 residues, 10198936-10199035Exon33: 23 residues, 10199125-10199189Exon34: 33 residues, 10201776-10201869Exon35: 39 residues, 10204001-10204113Exon36: 11 residues, 10204202-10204230Exon37: 54 residues, 10206159-10206316Exon38: 50 residues, 10206401-10206545Exon39: 74 residues, 10208368-10208584Exon40: 19 residues, 10215250-10215301Exon41: 11 residues, 10217020-10217047Exon42: 2 residues, -Jump to MYH13_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4266 10472575-10500192 ~-28K 15163(MYH3)(-)Loci: 4267 10524379-10541562 ~-17K 15164(SCO1)(-)Loci: 4265 10144907-10217047 ~-72K 15157(MYH13)(-)Link out to UCSC