SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0MYCB2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMYCBP2
DescriptionProbable ubiquitin ligase protein mycbp2 (ec 6.3.2.-) (myc binding protein 2) (protein associated with myc) (pam/highwire/rpm-1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is called PHR as it was original found in the proteins PAM ().ighwire () and RPM (). This domain can be duplicated in the highwire.AM and PRM sequences. The function of PHR is currently unclear.
  IPR012983:PHR
The regulator of chromosome condensation (RCC1) is a eukaryotic proteinwhich binds to chromatin and interacts with ran. nuclear GTP-bindingprotein .o promote the loss of bound GDP and the uptake offresh GTP.hus acting as a guanine-nucleotide dissociation stimulator (GDS).The interaction of RCC1 with ran probably plays an important role in theregulation of gene expression.RCC1.nown as PRP20 or SRM1 in yeast.im1 in fission yeast and BJ1 inDrosophila.s a protein that contains seven tandem repeats of a domain ofabout 50 to 60 amino acids. As shown in the following schematicrepresentation.he repeats make up the major part of the length of theprotein. Outside the repeat region.here is just a small N-terminal domain ofabout 40 to 50 residues and.n the Drosophila protein only. C-terminaldomain of about 130 residues.The RCC1-type of repeat is also found in the X-linked retinitis pigmentosaGTPase regulator . The RCC repeats form a beta-propellerstructure.
  IPR000408:Regulator of chromosome condensation, RCC1
Quality control of intracellular proteins is essential for cellular homeostasis. Molecular chaperones recognise and contribute to the refolding of misfolded or unfolded proteins.hereas the ubiquitin-proteasome system mediates the degradation of such abnormal proteins. Ubiquitin-protein ligases (E3s) determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. More recently.owever.-box proteins.hich contain a domain (the U box) of about 70 amino acids that is conserved from yeast to humans.ave been identified as a new type of E3 .The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc.nd is probably involved in mediating protein-protein interactions. . There are two different variants.he C3HC4-type and a C3H2C3-type.hich is clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as RING-H2 finger. The RING domain is a protein interaction domain which has been implicated in a range of diverse biological processes.E3 ubiquitin-protein ligase activity is intrinsic to the RING domain ofc-Cbl and is likely to be a general function of this domain; Various RINGfingers exhibit binding to E2 ubiquitin-conjugating enzymes (Ubcs) .Several 3D-structures for RING-fingers are known . The 3D structure of the zinc ligation system is unique to the RING domain and is referred to as the cross-brace motif. The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion.hilst pairs two and four bind the second.s illustrated in the following schematic representation:Note that in the older literature.ome RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family.lbeit with similar Cys-spacing (see ).
  IPR001841:Zinc finger, RING-type
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
IPR012983:PHR 
Evalue:-95.1938171386719 
Location:1688-1846IPR012983:PHR 
Evalue:-87.1191864013672 
Location:1197-1348IPR000408:RCC1 
Evalue:-5.74472761154175 
Location:920-968IPR001841:RING 
Evalue:-4.11350927482752 
Location:4391-4441IPR013783:Ig-like_fold 
Evalue:0 
Location:2224-2397IPR000408:RCC1_3 
Evalue:0 
Location:972-1029IPR000408:RCC1_3 
Evalue:0 
Location:563-618IPR000408:RCCNDNSATION 
Evalue:0 
Location:664-680IPR000408:RCCNDNSATION 
Evalue:0 
Location:645-658IPR000408:RCC1_2 
Evalue:0 
Location:907-917IPR001841:ZF_RING_1 
Evalue:0 
Location:0-0
SequencesProtein: MYCB2_HUMAN (4641 aa)
mRNA: AF075587 NM_015057
Local Annotation
Synapse Ontology
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00504
  Level 3 annotation:
    peptidylglycine monooxygenase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 279 residues, 76516793-76517629Exon2: 57 residues, 76523132-76523298Exon3: 38 residues, 76523946-76524054Exon4: 72 residues, 76527693-76527903Exon5: 38 residues, 76529121-76529229Exon6: 65 residues, 76530353-76530542Exon7: 36 residues, 76531658-76531762Exon8: 46 residues, 76533304-76533437Exon9: 45 residues, 76533797-76533926Exon10: 36 residues, 76534731-76534833Exon11: 42 residues, 76536750-76536870Exon12: 34 residues, 76538127-76538224Exon13: 96 residues, 76539716-76540000Exon14: 91 residues, 76540700-76540967Exon15: 29 residues, 76542766-76542847Exon16: 35 residues, 76548886-76548985Exon17: 82 residues, 76549283-76549523Exon18: 24 residues, 76550959-76551025Exon19: 77 residues, 76553562-76553787Exon20: 54 residues, 76553972-76554129Exon21: 55 residues, 76555167-76555328Exon22: 52 residues, 76559619-76559769Exon23: 68 residues, 76560967-76561167Exon24: 54 residues, 76562241-76562399Exon25: 58 residues, 76565300-76565468Exon26: 83 residues, 76567493-76567738Exon27: 58 residues, 76568447-76568617Exon28: 550 residues, 76569505-76571149Exon29: 43 residues, 76593508-76593631Exon30: 46 residues, 76597471-76597604Exon31: 77 residues, 76598453-76598678Exon32: 49 residues, 76611331-76611472Exon33: 41 residues, 76612182-76612299Exon34: 34 residues, 76612981-76613079Exon35: 40 residues, 76616580-76616696Exon36: 20 residues, 76618297-76618353Exon37: 74 residues, 76622869-76623085Exon38: 50 residues, 76628193-76628338Exon39: 59 residues, 76630072-76630245Exon40: 18 residues, 76634041-76634091Exon41: 31 residues, 76636589-76636677Exon42: 41 residues, 76637408-76637527Exon43: 77 residues, 76638464-76638690Exon44: 75 residues, 76640563-76640782Exon45: 35 residues, 76641749-76641850Exon46: 49 residues, 76643627-76643770Exon47: 61 residues, 76646446-76646625Exon48: 46 residues, 76648632-76648764Exon49: 71 residues, 76649883-76650090Exon50: 66 residues, 76652262-76652454Exon51: 76 residues, 76653836-76654058Exon52: 93 residues, 76657238-76657513Exon53: 66 residues, 76658006-76658199Exon54: 34 residues, 76661086-76661183Exon55: 30 residues, 76662387-76662471Exon56: 47 residues, 76663814-76663949Exon57: 32 residues, 76666288-76666380Exon58: 44 residues, 76677391-76677519Exon59: 44 residues, 76677608-76677734Exon60: 59 residues, 76678788-76678961Exon61: 53 residues, 76683302-76683456Exon62: 70 residues, 76684091-76684296Exon63: 41 residues, 76689975-76690093Exon64: 29 residues, 76696586-76696668Exon65: 42 residues, 76697570-76697690Exon66: 38 residues, 76705291-76705399Exon67: 36 residues, 76715194-76715296Exon68: 50 residues, 76715941-76716087Exon69: 70 residues, 76723286-76723491Exon70: 55 residues, 76729806-76729965Exon71: 55 residues, 76732563-76732723Exon72: 72 residues, 76733301-76733511Exon73: 27 residues, 76734188-76734265Exon74: 48 residues, 76735786-76735925Exon75: 26 residues, 76736064-76736138Exon76: 34 residues, 76739976-76740073Exon77: 26 residues, 76742127-76742199Exon78: 83 residues, 76742431-76742674Exon79: 67 residues, 76745607-76745804Exon80: 53 residues, 76750893-76751047Exon81: 74 residues, 76760296-76760512Exon82: 27 residues, 76768734-76768810Exon83: 70 residues, 76798609-76798815Exon84: 26 residues, 76799105-76799178Exon85: 2 residues, -Jump to MYCB2_HUMANExon1: 279 residues, 76516793-76517629Exon2: 57 residues, 76523132-76523298Exon3: 38 residues, 76523946-76524054Exon4: 72 residues, 76527693-76527903Exon5: 38 residues, 76529121-76529229Exon6: 65 residues, 76530353-76530542Exon7: 36 residues, 76531658-76531762Exon8: 46 residues, 76533304-76533437Exon9: 45 residues, 76533797-76533926Exon10: 36 residues, 76534731-76534833Exon11: 42 residues, 76536750-76536870Exon12: 34 residues, 76538127-76538224Exon13: 96 residues, 76539716-76540000Exon14: 91 residues, 76540700-76540967Exon15: 29 residues, 76542766-76542847Exon16: 35 residues, 76548886-76548985Exon17: 82 residues, 76549283-76549523Exon18: 24 residues, 76550959-76551025Exon19: 77 residues, 76553562-76553787Exon20: 54 residues, 76553972-76554129Exon21: 55 residues, 76555167-76555328Exon22: 52 residues, 76559619-76559769Exon23: 68 residues, 76560967-76561167Exon24: 54 residues, 76562241-76562399Exon25: 58 residues, 76565300-76565468Exon26: 83 residues, 76567493-76567738Exon27: 58 residues, 76568447-76568617Exon28: 550 residues, 76569505-76571149Exon29: 43 residues, 76593508-76593631Exon30: 46 residues, 76597471-76597604Exon31: 77 residues, 76598453-76598678Exon32: 49 residues, 76611331-76611472Exon33: 41 residues, 76612182-76612299Exon34: 34 residues, 76612981-76613079Exon35: 40 residues, 76616580-76616696Exon36: 20 residues, 76618297-76618353Exon37: 74 residues, 76622869-76623085Exon38: 50 residues, 76628193-76628338Exon39: 59 residues, 76630072-76630245Exon40: 18 residues, 76634041-76634091Exon41: 31 residues, 76636589-76636677Exon42: 41 residues, 76637408-76637527Exon43: 77 residues, 76638464-76638690Exon44: 75 residues, 76640563-76640782Exon45: 35 residues, 76641749-76641850Exon46: 49 residues, 76643627-76643770Exon47: 61 residues, 76646446-76646625Exon48: 46 residues, 76648632-76648764Exon49: 71 residues, 76649883-76650090Exon50: 66 residues, 76652262-76652454Exon51: 76 residues, 76653836-76654058Exon52: 93 residues, 76657238-76657513Exon53: 66 residues, 76658006-76658199Exon54: 34 residues, 76661086-76661183Exon55: 30 residues, 76662387-76662471Exon56: 47 residues, 76663814-76663949Exon57: 32 residues, 76666288-76666380Exon58: 44 residues, 76677391-76677519Exon59: 44 residues, 76677608-76677734Exon60: 59 residues, 76678788-76678961Exon61: 53 residues, 76683302-76683456Exon62: 70 residues, 76684091-76684296Exon63: 41 residues, 76689975-76690093Exon64: 29 residues, 76696586-76696668Exon65: 42 residues, 76697570-76697690Exon66: 38 residues, 76705291-76705399Exon67: 36 residues, 76715194-76715296Exon68: 50 residues, 76715941-76716087Exon69: 70 residues, 76723286-76723491Exon70: 55 residues, 76729806-76729965Exon71: 57 residues, 76732563-76732728Exon72: 70 residues, 76733306-76733511Exon73: 27 residues, 76734188-76734265Exon74: 48 residues, 76735786-76735925Exon75: 26 residues, 76736064-76736138Exon76: 34 residues, 76739976-76740073Exon77: 26 residues, 76742127-76742199Exon78: 83 residues, 76742431-76742674Exon79: 67 residues, 76745607-76745804Exon80: 53 residues, 76750893-76751047Exon81: 74 residues, 76760296-76760512Exon82: 27 residues, 76768734-76768810Exon83: 70 residues, 76798609-76798815Exon84: 26 residues, 76799105-76799178Exon85: 2 residues, -Jump to MYCB2_HUMAN  
Tune and view alternative isoforms