SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0MTRR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMTRR
DescriptionMethionine synthase reductase, mitochondrial precursor (ec 1.16.1.8) (msr).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005489 electron transporter activity (TAS)
0006520 amino acid metabolism (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1075776857.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Flavoprotein pyridine nucleotide cytochrome reductases (FPNCR) catalyse the interchange of reducing equivalents between one-electron carriers and the two-electron-carrying nicotinamide dinucleotides. The enzymes include ferredoxin:NADP+reductases (FNR) .lant and fungal NAD(P)H:nitrate reductases NADH:cytochrome b5 reductases .ADPH:P450 reductases .ADPH:sulphite reductases .itric oxide synthases .hthalate dioxygenase reductase .nd various other flavoproteins.
  IPR003097:FAD-binding
This domain is found in a number of proteins including flavodoxin and nitric-oxide synthase. Flavodoxins are electron-transfer proteins that function in various electron transport systems. They bind one FMN molecule.hich serves as aredox-active prosthetic group and are functionally interchangeable with ferredoxins. They have been isolated from prokaryotes.yanobacteria.nd some eukaryotic algae. Nitric oxide synthase () produces nitric oxide from L-arginie and NADPH. Nitric oxide acts as a messenger molecule in the body.
  IPR008254:Flavodoxin/nitric oxide synthase
Bacterial ferredoxin-NADP+ reductase may be bound to the thylakoid membrane or anchored to the thylakoid-bound phycobilisomes.Chloroplast ferredoxin-NADP+ reductase () may play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power. It is involved in the final step in the linear photosynthetic electron transport chain and has also been implicated in cyclic electron flow around photosystem I where its role would be to return electrons from ferredoxin to the cytochrome B-F complex.This domain is present in a variety of proteins that include.acterial flavohemoprotein.ammalian NADH-cytochrome b5 reductase.ukaryotic NADPH-cytochrome P450 reductase.itrate reductase from plants.itric-oxide synthase.acterial vanillate demethylase and others.
  IPR001433:Oxidoreductase FAD/NAD(P)-binding
Flavodoxins act in various electron-transport systems as functionalanalogues of ferredoxins . Although flavodoxins are found onlyin certain bacteria and algae the proteins share similaritywith a number of protein domains of both prokaryotic and eukaryotic origin .
  IPR001094:Flavodoxin-like
Flavoprotein pyridine nucleotide cytochrome reductases (FPNCR) catalyse the interchange of reducing equivalents between one-electron carriers and the two-electron-carrying nicotinamide dinucleotides. The enzymes include ferredoxin:NADP+reductases (FNR) .lant and fungal NAD(P)H:nitrate reductases NADH:cytochrome b5 reductases .ADPH:P450 reductases .ADPH:sulphite reductases .itric oxide synthases .hthalate dioxygenase reductase .nd various other flavoproteins.Despite functional similarities.PNCRs show no sequence similarity to NADPH:adrenodoxin reductases .or to bacterial ferredoxin:NAD+reductases and their homologues . To date.D-structures of 4 members of the family have been solved: Spinacia oleracea (spinach) ferredoxin:NADP+ reductase ; Pseudomonas cepacia phthalate dioxygenase reductase ; the flavoprotein domain of Zea mays (corn) nitrate reductase ; and Sus scrofa (pig) NADH:cytochrome b5 reductase . In all of them.he FAD-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel.hile the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet with 2 helices on each side) . In spite of such structural similarities.he level of amino acid identity between family members is at or below the limit of significance (e.g..itrate reductase is only 15% identical to FNR) .
  IPR001709:Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097:FAD_binding_1 
Evalue:-53.0555191040039 
Location:293-519IPR008254:Flavodoxin_1 
Evalue:-42.0132293701172 
Location:33-169IPR001433:NAD_binding_1 
Evalue:-24.2839965820313 
Location:568-689
SequencesProtein: MTRR_HUMAN (725 aa)
mRNA: NM_024010
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00597
  Level 3 annotation:
    [methionine synthase] reductase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 29 residues, 7922216-7922302Exon2: 53 residues, 7923882-7924036Exon3: 53 residues, 7926485-7926639Exon4: 41 residues, 7928370-7928488Exon5: 128 residues, 7931056-7931435Exon6: 43 residues, 7936267-7936390Exon7: 53 residues, 7938813-7938967Exon8: 31 residues, 7939727-7939816Exon9: 62 residues, 7942207-7942388Exon10: 16 residues, 7944484-7944527Exon11: 64 residues, 7945839-7946026Exon12: 41 residues, 7948846-7948965Exon13: 33 residues, 7949976-7950069Exon14: 63 residues, 7950177-7950360Exon15: 404 residues, 7953026-7954233Exon16: 2 residues, -Jump to MTRR_HUMAN  
Tune and view alternative isoforms