SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0MTR1B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMTNR1B
DescriptionMelatonin receptor type 1b (mel-1b-r) (mel1b melatonin receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0008502 melatonin receptor activity (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0007268 synaptic transmission (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1896461390.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Melatonin is secreted by the pineal gland during darkness . It regulatesa variety of neuroendocrine functions and is thought to play an essentialrole in circadian rhythms. Drugs that modify the action of melatonin.nd hence influence circadian cycles.re of clinical interest (for example.n the treatment of jet-lag). Melatonin receptors are found in theretina.n the pars tuberalis of the pituitary.nd in discrete areas ofthe brain. The receptor inhibits adenylyl cyclase via a pertussis-toxin-sensitive G-protein.robably of the Gi/Go class .
  IPR000025:Melatonin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Melatonin is secreted by the pineal gland during darkness. It regulatesa variety of neuroendocrine functions and is thought to play an essentialrole in circadian rhythms. Drugs that modify the action of melatonin.nd hence influence circadian cycles.re of clinical interest (for example.n the treatment of jet-lag). Melatonin receptors are found in theretina.n the pars tuberalis of the pituitary.nd in discrete areas ofthe brain. The receptor inhibits adenylyl cyclase via a pertussis-toxin-sensitive G-protein.robably of the Gi/Go class .Three sub-types have been cloned.esignated Mel1a.el1b and Mel1c.ogether with a closely-related orphan receptor.ermed Mel1x. The Mel1areceptor appears to mediate the circadian and reproductive effects of thehormone. In situ hybridisation indicates that Mel1a receptor messengerRNA is expressed in the hypothalamic suprachiasmatic nuclei and hypophysealpars tuberalis.resumed sites of the circadian and some of reproductiveactions of melatonin.espectively .
  IPR002278:Melatonin receptor type 1A
IPR000276:7tm_1 
Evalue:-45.0705795288086 
Location:57-308IPR002278:MELATONIN1AR 
Evalue:0 
Location:35-49
SequencesProtein: MTR1B_HUMAN (362 aa)
mRNA: NM_005959
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04286
  Level 3 annotation:
    melatonin receptor 1B
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 109 residues, 92342436-92342762Exon2: 447 residues, 92354260-92355596Exon3: 2 residues, -Jump to MTR1B_HUMAN  
Tune and view alternative isoforms