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0MTR1A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMTNR1A
DescriptionMelatonin receptor type 1a (mel-1a-r) (mel1a melatonin receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0008502 melatonin receptor activity (TAS)
0007623 circadian rhythm (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0007617 mating behavior (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Melatonin is secreted by the pineal gland during darkness . It regulatesa variety of neuroendocrine functions and is thought to play an essentialrole in circadian rhythms. Drugs that modify the action of melatonin.nd hence influence circadian cycles.re of clinical interest (for example.n the treatment of jet-lag). Melatonin receptors are found in theretina.n the pars tuberalis of the pituitary.nd in discrete areas ofthe brain. The receptor inhibits adenylyl cyclase via a pertussis-toxin-sensitive G-protein.robably of the Gi/Go class .
  IPR000025:Melatonin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Melatonin is secreted by the pineal gland during darkness. It regulatesa variety of neuroendocrine functions and is thought to play an essentialrole in circadian rhythms. Drugs that modify the action of melatonin.nd hence influence circadian cycles.re of clinical interest (for example.n the treatment of jet-lag). Melatonin receptors are found in theretina.n the pars tuberalis of the pituitary.nd in discrete areas ofthe brain. The receptor inhibits adenylyl cyclase via a pertussis-toxin-sensitive G-protein.robably of the Gi/Go class .Three sub-types have been cloned.esignated Mel1a.el1b and Mel1c.ogether with a closely-related orphan receptor.ermed Mel1x. The Mel1areceptor appears to mediate the circadian and reproductive effects of thehormone. In situ hybridisation indicates that Mel1a receptor messengerRNA is expressed in the hypothalamic suprachiasmatic nuclei and hypophysealpars tuberalis.resumed sites of the circadian and some of reproductiveactions of melatonin.espectively .
  IPR002278:Melatonin receptor type 1A
IPR000276:7tm_1 
Evalue:-44.0861854553223 
Location:44-295IPR002278:MELATONIN1AR 
Evalue:0 
Location:5-20IPR002278:MELATONIN1AR 
Evalue:0 
Location:317-332IPR002278:MELATONIN1AR 
Evalue:0 
Location:334-349IPR002278:MELATONIN1AR 
Evalue:0 
Location:22-36
SequencesProtein: MTR1A_HUMAN (350 aa)
mRNA: NM_005958
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04285
  Level 3 annotation:
    melatonin receptor 1A
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 302 residues, 187691802-187692705Exon2: 69 residues, 187713329-187713531Exon3: 2 residues, -Jump to MTR1A_HUMAN  
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Loci Cluster (Details)Loci: 4701 187745931-187881981 ~-136K 28507(FAT)(-)Loci: 4700 187691802-187713531 ~-22K 28506(MTNR1A)(-)Link out to UCSC